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· · COA & SDS available for every product · Same-day shipping on in-stock items Home By Target/Pathway/Disease By Signaling Pathways Metabolic Enzyme/Protease Proteasome KZR-616 - Moligand™, ≥98% , Inhibitor of proteasome 20S subunit beta 2;Inhibitor of proteasome 20S subunit beta 5;Inhibitor of proteasome 20S subunit beta 8;Inhibitor of proteasome 20S subunit beta 9, CAS No.1629677-75-3, Inhibitor of proteasome 20S subunit beta 2;Inhibitor of proteasome 20S subunit beta 5;Inhibitor of proteasome 20S subunit beta 8;Inhibitor of proteasome 20S subunit beta 9 KZR-616 - Moligand™, ≥98% , Inhibitor of proteasome 20S subunit beta 2;Inhibitor of proteasome 20S subunit beta 5;Inhibitor of proteasome 20S subunit beta 8;Inhibitor of proteasome 20S subunit beta 9, CAS No.1629677-75-3, Inhibitor of proteasome 20S subunit beta 2;Inhibitor of proteasome 20S subunit beta 5;Inhibitor of proteasome 20S subunit beta 8;Inhibitor of proteasome 20S subunit beta 9
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98% Synonyms
(2S,3R)-N-((S)-3-(cyclopent-1-en-1-yl)-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propanamide | BDBM50526811 | ZETOMIPZOMIB [INN] | D-Erythro-3-pentulose, 4,5-anhydro-1-(1-cyclop
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
KZR-616（Zetomipzomib）, a first-in-class inhibitor of the immunoproteasome, selectively targets the LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50: 131/179 nM=hLMP7/mLMP7) subunits of the immunoproteasome. KZR-616（Zetomipzomib）has the potential for the research of multiple autoimmune diseases.
Specifications Synonyms
(2S, 3R)-N-((S)-3-(cyclopent-1-en-1-yl)-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propanamide | BDBM50526811 | ZETOMIPZOMIB [INN] | D-Erythro-3-pentulose, 4, 5-anhydro-1-(1-cyclop
Specifications & Purity
Moligand™, ≥98%
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
Inhibitor of proteasome 20S subunit beta 2;Inhibitor of proteasome 20S subunit beta 5;Inhibitor of proteasome 20S subunit beta 8;Inhibitor of proteasome 20S subunit beta 9
Names and Identifiers Canonical Smiles CC(C(=O)NC(C(C1=CC=C(C=C1)OC)O)C(=O)NC(CC2=CCCC2)C(=O)C3(CO3)C)NC(=O)CN4CCOCC4 IUPAC Name (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide InChIKey GHYOCDFICYLMRF-UTIIJYGPSA-N INCHI 1S/C30H42N4O8/c1-19(31-24(35)17-34-12-14-41-15-13-34)28(38)33-25(26(36)21-8-10-22(40-3)11-9-21)29(39)32-23(16-20-6-4-5-7-20)27(37)30(2)18-42-30/h6,8-11,19,23,25-26,36H,4-5,7,12-18H2,1-3H3,(H,31,35)(H,32,39)(H,33,38)/t19-,23-,25-,26+,30+/m0/s1 Isomeric SMILES C[C@@H](C(=O)N[C@@H]([C@@H](C1=CC=C(C=C1)OC)O)C(=O)N[C@@H](CC2=CCCC2)C(=O)[C@]3(CO3)C)NC(=O)CN4CCOCC4 Alternate CAS 1629677-75-3；2170983-62-5 MeSH Entry Terms (2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide;KZR-616 Molecular Weight 586.68
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organic acids and derivatives Class Carboxylic acids and derivatives Subclass Amino acids, peptides, and analogues Intermediate Tree Nodes Peptides Direct Parent Oligopeptides Alternative Parents Phenylalanine and derivatives N-acyl-alpha amino acids and derivatives Alpha amino acid amides Alanine and derivatives Phenoxy compounds Methoxybenzenes Anisoles Alkyl aryl ethers Morpholines Fatty amides Trialkylamines Secondary carboxylic acid amides Secondary alcohols Ketones Oxacyclic compounds Epoxides Dialkyl ethers Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Aromatic alcohols Molecular Framework Aromatic heteromonocyclic compounds Substituents Alpha-oligopeptide - Phenylalanine or derivatives - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Alanine or derivatives - Alpha-amino acid or derivatives - N-substituted-alpha-amino acid - Phenoxy compound - Methoxybenzene - Phenol ether - Anisole - Alkyl aryl ether - Fatty acyl - Benzenoid - Oxazinane - Morpholine - Fatty amide - Monocyclic benzene moiety - Tertiary aliphatic amine - Tertiary amine - Secondary carboxylic acid amide - Secondary alcohol - Ketone - Carboxamide group - Amino acid or derivatives - Oxacycle - Azacycle - Organoheterocyclic compound - Ether - Oxirane - Dialkyl ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Aromatic alcohol - Organooxygen compound - Organonitrogen compound - Carbonyl group - Amine - Alcohol - Aromatic heteromonocyclic compound Description This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Sensitivity Moisture sensitive Molecular Weight 586.700 g/mol XLogP3 0.400 Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 9 Rotatable Bond Count 14 Exact Mass 586.3 Da Monoisotopic Mass 586.3 Da Topological Polar Surface Area 159.000 Ų Heavy Atom Count 42 Formal Charge 0 Complexity 1010.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 5 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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