L-Leucine - Animal Free, USP, JP, Moligand™, Ph.Eur., for cell culture, ≥98.5% , CAS No.61-90-5

CAS: 61-90-5 Cat. No.: L433130 Fórmula: C₆H₁₃NO₂ Peso molecular: 131.17 Beilstein Registry Number: 4437 Número CE: 200-522-0

GRADE & PURITY Animal Free, USP, JP, Moligand™, Ph.Eur., for Cell culture, ≥98.5%

Synonyms

(S)-2-Amino-4-methylpentanoic acid | NSC-46709 | .alpha.-Amino-.gamma.-methylvaleric acid | LEUCINE [HSDB] | 2-Amino-4-methylvaleric acid (L) | L-Leu | GMW67QNF9C | IS_LEUCINE-5,5,5-D3 | MFCD00002617 | (S)-2-Amino-4-methylpentanoate | L-LEUCINE [USP-RS] |

Storage

Protected from light,Room temperature

Shipped In

Normal

Visão geral

Application

L-leucine has been used as a hypertrophic agent to monitor its effects on myotubes. It has also been used as a component of PMG media for culturing yeast.

Specifications

Sinónimos

(S)-2-Amino-4-methylpentanoic acid | NSC-46709 | .alpha.-Amino-.gamma.-methylvaleric acid | LEUCINE [HSDB] | 2-Amino-4-methylvaleric acid (L) | L-Leu | GMW67QNF9C | IS_LEUCINE-5,5,5-D3 | MFCD00002617 | (S)-2-Amino-4-methylpentanoate | L-LEUCINE [USP-RS] |

Especificações e pureza

Animal Free, USP, JP, Moligand™, Ph.Eur., for cell culture, ≥98.5%

Mecanismos bioquímicos e fisiológicos

Leucine is a non-glucogenic, essential amino acid. It is a branched-chain amino acid that is a structural component of proteins. Leucine positively influences insulin release to eliminate toxic sugars out of the blood. The degradation of leucine leads to

Condições de armazenamento de armazenamento

Protected from light,Room temperature

Enviado em

Normal

Grau

Animal Free, for Cell culture, JP, Moligand™, Ph.Eur., USP

Pureza

≥98.5%

Nomes e identificadores

• Pubchem Sid: 504750999
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504750999
• Sorrisos canónicos: CC(C)CC(C(=O)O)N
• IUPAC Name: (2S)-2-amino-4-methylpentanoic acid
• InChIKey: ROHFNLRQFUQHCH-YFKPBYRVSA-N
• INCHI: 1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
• SMILES isoméricas: CC(C)C[C@@H](C(=O)O)N
• WGK Alemanha: 1
• Peso molecular: 131.17
• Beilstein: 4437
• Reaxy-Rn: 636005
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=636005&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Classe Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Leucine and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Classe: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Leucine and derivatives
• Alternative Parents: L-alpha-amino acids Methyl-branched fatty acids Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Leucine or derivatives - Alpha-amino acid - L-alpha-amino acid - Branched fatty acid - Methyl-branched fatty acid - Fatty acid - Fatty acyl - Amino acid - Monocarboxylic acid or derivatives - Carboxylic acid - Organic oxide - Organopnictogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Carbonyl group - Organic oxygen compound - Amine - Organic nitrogen compound - Hydrocarbon derivative - Aliphatic acyclic compound
• Descrição: This compound belongs to the class of organic compounds known as leucine and derivatives. These are compounds containing leucine or a derivative thereof resulting from reaction of leucine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: Common amino acids

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

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CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

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CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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Homo sapiens (32628 Activities)

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SLC7A5 Tchem L-type amino acid transporter 1 (388 Activities)

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ALPL Tchem Alkaline phosphatase, tissue-nonspecific isozyme (1551 Activities)

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Liver microsomes (16955 Activities)

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PLAA Tchem Phospholipase A-2-activating protein (44 Activities)

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SLC36A1 Tchem Proton-coupled amino acid transporter 1 (102 Activities)

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SLC16A10 SLC16A10 protein (28 Activities)

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Alvos associados (não humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

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Iap Intestinal alkaline phosphatase (419 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Staphylococcus epidermidis (22802 Activities)

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Escherichia coli (133304 Activities)

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Bacillus subtilis (32866 Activities)

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Aspergillus fumigatus (16427 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Candida parapsilosis (8521 Activities)

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Plasmodium berghei (192651 Activities)

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Mus musculus (284745 Activities)

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Sporothrix schenckii (1580 Activities)

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MDCK (10148 Activities)

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RAW264.7 (28094 Activities)

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NIH3T3 (5395 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Trichophyton mentagrophytes (4846 Activities)

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Slc16a10 Monocarboxylate transporter 10 (73 Activities)

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SLC16A2 Monocarboxylate transporter 8 (28 Activities)

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Lipopolysaccharide (LPS) (376 Activities)

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SARS-CoV-2 (38078 Activities)

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Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: 1 M HCl: 50mg/mL
• Sensibilidade: Sensitive to light; Sensitivity to humidity
• Rotação específica [α]: [α]20/D +15.5±0.5°, c = 5% in 5 M HCl
• Ponto de ebulição (°C): 122-134 °C
• Ponto de fusão (°C): 270-340 °C (decomposition)
• Peso molecular: 131.170 g/mol
• XLogP3: -1.500
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 131.095 Da
• Monoisotopic Mass: 131.095 Da
• Topological Polar Surface Area: 63.300 Ų
• Heavy Atom Count: 9
• Formal Charge: 0
• Complexity: 101.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥98.5% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What does Animal Free mean?

Animal Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

What does USP mean?

USP indicates that the material complies with the published monographs of the relevant pharmacopoeia (USP). Specifications include identity, assay, impurity limits, residual solvents and other tests defined in the monograph. USP-compliant material is suitable for pharmacopoeia-compliant pharmaceutical use, including pharmaceutical manufacturing, QC and regulatory submission.

How should this product be stored?

Store at room temperature, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships under standard ambient conditions. No temperature-controlled packaging is required.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 61-90-5, the molecular formula is C6H13NO2, and the molecular weight is 131.17 g/mol. InChIKey ROHFNLRQFUQHCH-YFKPBYRVSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.