≥97% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
L48H37 is an analog of Curcumin with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is used for the research of sepsis or lung injury treatment
In Vitro
L48H37 inhibits LPS-induced inflammation, particularly TNF-α and IL-6 production and gene expression in mouse macrophages. L48H37 (0-20 µM; 24 hours) decreases the viability of A549 and H460 cells with IC 50 values of 5.3 µM and 2.3 µM, respectively, which is more effective compared to curcumin in lung cancer cells. It shows a low cytotoxicity on normal human lung epithelial cells (BEAS-2B) with IC 50 of 21 μM. L48H37 (1, 2, or 4 µM; 16 hours) dose‐dependently inhibited the expression of p‐Cdc2 and Cdc2, and increases the expression of p53. It also shows increased levels of cleaved poly (ADP‐ribosyl) polymerase (PARP) and reduced levels of anti‐apoptotic protein Bcl‐2 in H460 and A549 cells. L48H37 (4 µM; 16 hours) rapidly induces intracellular ROS levels dose-dependently as detected by increased DCF levels in H460 and A549 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: A549 and H460 cells; BEAS-2B cells Concentration: 0.625, 1.25, 2.5, 5, 7.5, 10, and 20 µM Incubation Time: 24 hours Result: Inhibited lung cancer cells growth in a concentration-dependent manner. Western Blot AnalysisCell Line: A549 and H460 cells Concentration: 0.625, 1.25, 2.5, 5, 7.5, 10, and 20 µM Incubation Time: 24 hours Result: Decreased p‐Cdc2, Cdc2, and Bcl‐2 expression in 2 lung cancer cells.
In Vivo
L48H37 (intraperitoneal injection; 5 mg or 10 mg/kg; once daily; 11‐day ) inhibits H460 xenograft tumor growth and exhibits anti‐tumor activity in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 5‐week‐old athymic BALB/cA nu/nu female mice (18‐22 g)Dosage: 5 mg or 10 mg/kg Administration: Intraperitoneal injection; once daily; 11‐day Result: Reduced tumor wet weights as compared to vehicle control. Decreased the levels of p‐STAT3, and increased the levels of p‐EIF2α and ATF4 in vivo. Exhibited no significant structural changes in mice.
Form:Solid
IC50& Target:TLR4
| SMILES isoméricas | CCN1CC(=CC2=CC(=C(C(=C2)OC)OC)OC)C(=O)C(=CC3=CC(=C(C(=C3)OC)OC)OC)C1 |
|---|---|
| PubChem CID | 4201646 |
| Peso molecular | 483.55 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubilidade | DMSO : 50 mg/mL (103.40 mM; Need ultrasonic) |
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