Levonorgestrel - Moligand™, 10mM in DMSO , Progesterone receptor agonist, CAS No.797-63-7, Progesterone receptor agonist

CAS: 797-63-7 Cat. No.: L409272 Fórmula: C₂₁H₂₈O₂ Peso molecular: 312.45 Número CE: 212-349-8

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

D-Norgestrel | 13-ethyl-17-hydroxy-, (17α)-18,19-Dinorpregn-4-en-20-yn-3-one

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Levonorgestrel (D-Norgestrel) is a female hormone that prevents ovulation.
In vitro

Levonorgestrel suppresses the stimulation of progesterone secretion induced by oLH, dibutyryl-cAMP and Pregnenolone in rats luteal cells. Levonorgestrel also inhibits constrictions evoked by either a high potassium (K(+)) solution or phorbol myristate acetate (PMA) in the absence and presence of extracellular calcium (Ca(2+)). Levonorgestrel depresses contractions evoked by Ca(2+) and reduces (45)Ca(2+) influx in depolarized veins. Levonorgestrel increases levels of cyclic AMP and inhibits PMA-induced activation of protein kinase C in veins. Levonorgestrel causes endothelium-independent relaxations of jugular veins via inhibition of Ca(2+) entry and of protein kinase Cactivation. Levonorgestrel inhibition of both estrogen-induced pituitary weight increment and hyperprolactinemia is reduced by mifepristone, whereas Flutamide is unable to block Levonorgestrel effects

In vivo

Levonorgestrel down-regulates the mRNA expression of follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), estrogen receptor (ER) β and progesterone receptor (PR) in the ovary, and ERα and PR in the uterus of Mongolian gerbils. Levonorgestrel causes a significant upregulation of the mRNA expression of the gene encoding luteinising hormone β-subunit (lhβ) and the suppression of the mRNA expression of the gene encoding follicle-stimulating hormone β-subunit (fshβ) in the pituitary of both male and female roach. Levonorgestrel disrupts the reproductive system of pubertalroach by affecting the pituitary gonadotropin expression and the sex steroid levels in pubertal roach (Rutilus rutilus).
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

D-Norgestrel | 13-ethyl-17-hydroxy-, (17α)-18,19-Dinorpregn-4-en-20-yn-3-one

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Levonorgestrel (D-Norgestrel) is a female hormone that prevents ovulation.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

AGONIST

Mecanismo de ação

Progesterone receptor agonist

Nomes e identificadores

• SMILES isoméricas: CC[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC(=O)CC[C@H]34
• WGK Alemanha: 3
• RTECS: JF8259000
• Peso molecular: 312.45
• Reaxy-Rn: 24733492
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24733492&ln=

Alvos associados (humanos)

PGR Tclin Progesterone receptor (0 Activities)

Discover Target: PGR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 30 mg/mL (197.17 mM); Ethanol: 30 mg/mL (197.17 mM); Water: Insoluble
• Rotação específica [α]: [α]D：-34~-31° (C=1,CHCl3)
• Ponto de fusão (°C): 236℃

Referências

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