LGD-6972 - Moligand™, 10mM in DMSO , CAS No.1207989-09-0

CAS: 1207989-09-0 Cat. No.: L655135 Fórmula: C₄₃H₄₆N₂O₅S Peso molecular: 702.90 PubChem CID: 44625560

GRAU & PUREZA Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

LGD-6972 is a selective and orally active Glukagon receptor antagonist. LGD-6972 has the potential for type 2 diabetes research.

In Vitro

In vitro, LGD-6972 binds competitively to Glukagon receptor (GCGR) with high affinity and selectivity, suppressing both cAMP and glucose production. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In vivo, LGD-6972 reduces acute Glukagon-stimulated hyperglycaemia as well as the hyperglycaemia observed in diabetic mouse models. The pharmacological activity of LGD-6972 appears to be mediated primarily by inhibiting Glukagon receptor signaling . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Especificações

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

LGD-6972 is a selective and orally active Glukagon receptor antagonist. LGD-6972 has the potential for type 2 diabetes research.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Nomes e identificadores

SMILES isoméricas

CC1=CC(=C(C(=C1)C)C2=CC=C(C=C2)NC(=O)[C@H](CC3=CC=C(C=C3)C(=O)NCCS(=O)(=O)O)C4=CC=C(C=C4)C5=CC=C(C=C5)C(C)(C)C)C

CAS alternativo

1207989-09-0

PubChem CID

44625560

Termos de entrada MeSH

2-((4-((2R)-2-(4-(4-tert-butylphenyl)phenyl)-3-oxo-3-(4-(2,4,6-trimethylphenyl)anilino)propyl)benzoyl)amino)ethanesulfonic acid;LGD-6972;RVT-1502

Peso molecular

702.90