Lin28 1632 - ≥98%(HPLC) , CAS No.108825-65-6

CAS: 108825-65-6 Cat. No.: L287258 Fórmula: C₁₅H₁₅N₅O Peso molecular: 281.31

GRADE & PURITY ≥98%(HPLC)

Synonyms

Lin28 1632 | Lin-28 1632 | N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]-pyridazin-6-yl)phenyl]acetamide | N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide | CCG-42206 | DTXSID20371981 | HMS1448E05 | Lin281632 | Lin-281632 | WP

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Product Describtion:

Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28-let-7 antagonist 1 inhibits Lin28A binding to pre-let-7a-2, with an IC50 of 8 μM. Lin28-let-7 antagonist 1 inhibits proliferation in human cancer cells.

Specifications

Sinónimos

Lin28 1632 | Lin-28 1632 | N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]-pyridazin-6-yl)phenyl]acetamide | N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide | CCG-42206 | DTXSID20371981 | HMS1448E05 | Lin281632 | Lin-281632 | WP

Especificações e pureza

≥98%(HPLC)

Mecanismos bioquímicos e fisiológicos

RNA binding protein Lin28 inhibitor (IC50= 8μM). Blocks binding of Lin28 to let-7 pre-micro RNA. Inhibits stemness and induces differentiation of murine ESCs. Increaseslet-7miRNA and suppresses PD-L1 expression in multiple human cancer cell lines. Inhibit

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

ANTAGONIST

Pureza

≥98%(HPLC)

Nomes e identificadores

• Pubchem Sid: 488192879
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488192879
• Sorrisos canónicos: CC1=NN=C2N1N=C(C=C2)C3=CC(=CC=C3)N(C)C(=O)C
• IUPAC Name: N-methyl-N-[3-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide
• InChIKey: WPAQLESUVYGUJZ-UHFFFAOYSA-N
• INCHI: 1S/C15H15N5O/c1-10-16-17-15-8-7-14(18-20(10)15)12-5-4-6-13(9-12)19(3)11(2)21/h4-9H,1-3H3
• SMILES isoméricas: CC1=NN=C2N1N=C(C=C2)C3=CC(=CC=C3)N(C)C(=O)C
• Peso molecular: 281.31
• Reaxy-Rn: 13479104
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13479104&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Diazines
      • Subclass Pyridazines and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Diazines
• Subclass: Pyridazines and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpyridazines
• Alternative Parents: Acetanilides Triazolopyridazines Triazoles Tertiary carboxylic acid amides Heteroaromatic compounds Acetamides Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenylpyridazine - Acetanilide - Triazolopyridazine - Anilide - Monocyclic benzene moiety - Benzenoid - Azole - Tertiary carboxylic acid amide - 1,2,4-triazole - Acetamide - Heteroaromatic compound - Carboxamide group - Carboxylic acid derivative - Azacycle - Organopnictogen compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organic oxide - Organic oxygen compound - Hydrocarbon derivative - Carbonyl group - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as phenylpyridazines. These are organic compounds containing a pyridazine ring substituted by a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)

Discover Target: BRD4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

Discover Target: ATAD5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Alvos associados (não humanos)

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: Solvent:DMSO, Max Conc. mg/mL: 28.13, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 28.13, Max Conc. mM: 100
• Peso molecular: 281.310 g/mol
• XLogP3: 1.200
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 281.128 Da
• Monoisotopic Mass: 281.128 Da
• Topological Polar Surface Area: 63.400 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 390.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1