Loureirin A - ≥98% , CAS No.119425-89-7

CAS: 119425-89-7 Cat. No.: L412862 Fórmula: C₁₇H₁₈O₄ Peso molecular: 286.32

GRADE & PURITY ≥98%

Synonyms

ZB1869 | AS-78728 | 3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)propan-1-one | AC-34430 | s3241 | SCHEMBL7187176 | FT-0715269 | Loureirin A | HY-N1505 | RSAIVLRELNGZEY-UHFFFAOYSA-N | AKOS030573608 | MFCD10566607 | LoureirinA | DTXSID201318286 | LMPK1212060

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Information

Loureirin A Loureirin A is a flavonoid extracted from the red resin of the herbs of Dracaena cochinchinensis , which is known as Dragon's Blood. Loureirin A inhibits platelet activation by an impairment of PI3K/Akt signaling. Loureirin A inhibits Akt phosphorylation.

Targets

Akt

Specifications

Sinónimos

ZB1869 | AS-78728 | 3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)propan-1-one | AC-34430 | s3241 | SCHEMBL7187176 | FT-0715269 | Loureirin A | HY-N1505 | RSAIVLRELNGZEY-UHFFFAOYSA-N | AKOS030573608 | MFCD10566607 | LoureirinA | DTXSID201318286 | LMPK1212060

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

Loureirin A is a flavonoid extracted from the red resin of the herbs of Dracaena cochinchinensis, which is known as Dragon's Blood. Loureirin A inhibits platelet activation by an impairment of PI3K/Akt signaling. Loureirin A inhibits Akt phosphorylation.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥98%

Nomes e identificadores

• Pubchem Sid: 504763587
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504763587
• Sorrisos canónicos: COC1=CC(=C(C=C1)CCC(=O)C2=CC=C(C=C2)O)OC
• IUPAC Name: 3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)propan-1-one
• InChIKey: RSAIVLRELNGZEY-UHFFFAOYSA-N
• INCHI: 1S/C17H18O4/c1-20-15-9-5-13(17(11-15)21-2)6-10-16(19)12-3-7-14(18)8-4-12/h3-5,7-9,11,18H,6,10H2,1-2H3
• SMILES isoméricas: COC1=CC(=C(C=C1)CCC(=O)C2=CC=C(C=C2)O)OC
• Peso molecular: 286.32
• Reaxy-Rn: 11212261
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11212261&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Classe Linear 1,3-diarylpropanoids
      • Subclass Chalcones and dihydrochalcones

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Classe: Linear 1,3-diarylpropanoids
• Subclass: Chalcones and dihydrochalcones
• Intermediate Tree Nodes: Not available
• Direct Parent: Retro-dihydrochalcones
• Alternative Parents: Cinnamylphenols Alkyl-phenylketones Butyrophenones Dimethoxybenzenes Phenoxy compounds Benzoyl derivatives Aryl alkyl ketones Anisoles Alkyl aryl ethers 1-hydroxy-2-unsubstituted benzenoids Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Retro-dihydrochalcone - Cinnamylphenol - Alkyl-phenylketone - Butyrophenone - Dimethoxybenzene - M-dimethoxybenzene - Phenylketone - Benzoyl - Phenol ether - Phenoxy compound - Aryl ketone - Aryl alkyl ketone - Anisole - Methoxybenzene - Phenol - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - Benzenoid - Monocyclic benzene moiety - Ketone - Ether - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Aromatic homomonocyclic compound
• Descrição: This compound belongs to the class of organic compounds known as retro-dihydrochalcones. These are a form of normal dihydrochalcones that are structurally distinguished by the lack of oxygen functionalities at the C2'- and C6'-positions.
• External Descriptors: Chalcones and dihydrochalcones

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

ALB Tchem Serum albumin (2651 Activities)

Discover Target: ALB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HT-1080 (3966 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PANC-1 (6144 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Alvos associados (não humanos)

Helicobacter pylori (3113 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 100 mg/mL (349.25 mM)
• Peso molecular: 286.320 g/mol
• XLogP3: 3.100
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 286.121 Da
• Monoisotopic Mass: 286.121 Da
• Topological Polar Surface Area: 55.800 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 323.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1