luminol - 10mM in DMSO , CAS No.521-31-3

CAS: 521-31-3 Cat. No.: L424466 Fórmula: C₈H₇N₃O₂ Peso molecular: 177.16 Beilstein Registry Number: 383929 Número CE: 208-309-4

GRAU & PUREZA 10mM in DMSO

Synonyms

LUMINOL|3-Aminophthalhydrazide|521-31-3|5-amino-2,3-dihydrophthalazine-1,4-dione|5-Amino-2,3-dihydro-1,4-phthalazinedione|3-Aminophthalic hydrazide|1,4-Phthalazinedione, 5-amino-2,3-dihydro-|5-Amino-1,2,3,4-tetrahydrophthalazine-1,4-dione|3-Aminophthalylh

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Luminol is a reagent for the generation of chemiluminescence in biological assays including nitric oxide and myeloperoxidase assay. Luminol is converted to a dianion in basic solution, which is then oxidized with H2O2/Cu2+ to form N2 and an aminophthalate ion in an electronically excited state. The aminophthalate ion emits a photon of wavelength 424 nm.
A chemiluminescence generating reagent for biological and metal cation assays

Especificações

Sinónimos

LUMINOL | 3-Aminophthalhydrazide | 521-31-3 | 5-amino-2,3-dihydrophthalazine-1,4-dione | 5-Amino-2,3-dihydro-1,4-phthalazinedione | 3-Aminophthalic hydrazide | 1,4-Phthalazinedione, 5-amino-2,3-dihydro- | 5-Amino-1,2,3,4-tetrahydrophthalazine-1,4-dione | 3-Aminophthalylh

Especificações e pureza

10mM in DMSO

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Nomes e identificadores

Pubchem Sid

528776636

Sorrisos canónicos

C1=CC2=C(C(=C1)N)C(=O)NNC2=O

IUPAC Name

5-amino-2,3-dihydrophthalazine-1,4-dione

InChIKey

HWYHZTIRURJOHG-UHFFFAOYSA-N

INCHI

1S/C8H7N3O2/c9-5-3-1-2-4-6(5)8(13)11-10-7(4)12/h1-3H,9H2,(H,10,12)(H,11,13)

SMILES isoméricas

C1=CC2=C(C(=C1)N)C(=O)NNC2=O

WGK Alemanha

3

RTECS

TH8890060

Peso molecular

177.16

Beilstein

383929

Reaxy-Rn

383929

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=383929&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Diazanaphthalenes
      • Subclass Benzodiazines
        • Level5 Phthalazines
          • Level6 Phthalazinones

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Diazanaphthalenes
• Subclass: Benzodiazines
• Intermediate Tree Nodes: Phthalazines
• Direct Parent: Phthalazinones
• Alternative Parents: Pyridazinones Benzenoids Vinylogous amides Heteroaromatic compounds Lactams Azacyclic compounds Primary amines Organopnictogen compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phthalazinone - Pyridazinone - Pyridazine - Benzenoid - Heteroaromatic compound - Vinylogous amide - Lactam - Azacycle - Amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Primary amine - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as phthalazinones. These are compounds containing a phthalazine bearing a ketone group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

TNF Tclin TNF-alpha (1897 Activities)

Discover Target: TNF

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

Discover Target: ALDH1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAN Tchem GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 (21853 Activities)

Discover Target: RAN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Alvos associados (não humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Qtrt1 tRNA-guanine transglycosylase (21 Activities)

Discover Target: Qtrt1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Sensibilidade: Air Sensitive
• Ponto de fusão (°C): ≥300°C
• Peso molecular: 177.160 g/mol
• XLogP3: 0.300
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 177.054 Da
• Monoisotopic Mass: 177.054 Da
• Topological Polar Surface Area: 84.200 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 254.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1