Megestrol Acetate - 10mM in DMSO , Progesterone receptor agonist, CAS No.595-33-5, Progesterone receptor agonist

CAS: 595-33-5 Cat. No.: M408438 Fórmula: C₂₄H₃₂O₄ Peso molecular: 384.52 Beilstein Registry Number: 8(4)2431 Número CE: 209-864-5

GRADE & PURITY 10mM in DMSO

Synonyms

BDH1298, SC10363 | (8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Megestrol acetate (BDH1298, SC10363) is a syntheticprogestogen, used to treat breast cancer and loss of appetite.
In vitro

Megestrol acetate inhibits the expression of cytoplasmic aromatase through nuclear C/EBPβ in reperfusion injury-induced ischemic rat hippocampus. Megestrol acetate significantly increases the proliferation, migration, and adipogenic differentiation of adipose-derived stem cells (ASCs) in a dose-dependent manner. Megestrol acetate also upregulates genes downstream of glucocorticoid receptor (GR) in ASCs.

In vivo

Megestrol acetate significantly decreases the circulating concentrations of estradiol (E2) and testosterone (T) in female fish or 11-ketotestosterone (11-KT) in male fish. Megestrol acetate exposure significantly downregulates the transcription of certain genes along the hypothalamic-pituitary-gonadal (HPG) axis. Megestrol acetate produces a progressive deterioration in glucose tolerance, with a significant increase in mean fasting plasma glucose concentrations and decrease in mean plasma glucose clearance rates after 6 months and 12 months of treatment in cats. Megestrol acetate also produces a progressive decrease in both resting plasma cortisol concentrations and cortisol concentrations after ACTH stimulation in cats. Megestrol acetate (50 mg/kg/day) for 9 days significantly increases food and water intake compared with untreated controls. Megestrol acetate (50 mg/kg/day) significantly (90-140%) increases in neuropeptide Y concentrations in the arcuate nucleus (where neuropeptide Y is synthesized), in the lateral hypothalamic area (through which arcuate neurones project) and in the medial preoptic area, ventromedial nucleus and dorsomedial nucleus in rats.
Cell Data

cell lines：HCT116, MDA-MB-231, SNU-5, and MKN45 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

BDH1298, SC10363 | (8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Megestrol acetate (BDH1298, SC10363) is a synthetic progestogen, used to treat breast cancer and loss of appetite.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

AGONIST

Mecanismo de ação

Progesterone receptor agonist

Nomes e identificadores

• SMILES isoméricas: CC1=C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C
• RTECS: TU4075000
• Peso molecular: 384.52
• Beilstein: 8(4)2431
• Reaxy-Rn: 3489305
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3489305&ln=

Alvos associados (humanos)

NR3C1 Tclin Glucocorticoid receptor (2 Activities)

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro
• Rotação específica [α]: 11° (C=2,CHCl3)
• Ponto de fusão (°C): 218 °C