Metoxi-X04 - ≥97% , CAS No.863918-78-9

CAS: 863918-78-9 Cat. No.: M276110 Fórmula: C₂₃H₂₀O₃ Peso molecular: 344.4

GRADE & PURITY ≥97%

Synonyms

2,5-Bis(2-(4-hidroxifenil)vinil)anisol | 4,4'-[(2-metoxi-1,4-fenileno)di-(1E)-2,1-etenodiil]bis-feno

Storage

Armazenar a -20°C

Shipped In

Arca de gelo + almofadas de gelo

Visão geral

Descrição：

O metoxi-X04 é uma sonda fluorescente permeável ao cérebro para amiloide-β (Aβ) para detetar e quantificar placas, emaranhados e amiloide cerebrovascular.1 Ele exibe alta afinidade de ligação in vitro (Ki = 26,8 nM) para depósitos de folhas β fibrilares e é usado para gerar imagens de placas Aβ no cérebro de camundongos APP / PS1 vivos, um modelo transgênico da doença de Alzheimer familiar.1,2 Para a imagiologia in vivo, os ratinhos APP/PS1 foram injectados com metoxi-X04 numa dose de 10 mg/kg, i.p., 24 horas antes da imagiologia com dois fotões.2 O metoxi-X04 apresenta um pico de excitação a 750 nm com emissão entre 460 e 500 nm.2

Specifications

Sinónimos

2,5-Bis(2-(4-hidroxifenil)vinil)anisol | 4,4'-[(2-metoxi-1,4-fenileno)di-(1E)-2,1-etenodiil]bis-feno

Especificações e pureza

≥97%

Mecanismos bioquímicos e fisiológicos

Marcador fluorescente de amiloide β permeável à barreira hemato-encefálica. Fluoróforo azul. Derivado do Vermelho do Congo e da Crisamina G. Liga-se seletivamente a depósitos de folhas β fibrilares com elevada afinidade (K i = 26,8 nM).

Condições de armazenamento de armazenamento

Armazenar a -20°C

Enviado em

Arca de gelo + almofadas de gelo

Nota

Sempre que possível, deve preparar e utilizar as soluções no mesmo dia. No entanto, se precisar de preparar soluções de reserva com antecedência, recomendamos que guarde a solução como alíquotas em frascos hermeticamente fechados a -20°C. Em geral, estas podem ser utilizadas durante um mês. Antes de utilizar, e antes de abrir o frasco para injectáveis, recomendamos que deixe o seu produto equilibrar à temperatura ambiente durante pelo menos 1 hora. Precisa de mais conselhos sobre solubilidade, utilização e manuseamento? Para mais informações, visite a nossa página de perguntas frequentes (FAQ).

Pureza

≥97%

Nomes e identificadores

• Pubchem Sid: 504768014
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504768014
• Sorrisos canónicos: COC1=C(C=CC(=C1)C=CC2=CC=C(C=C2)O)C=CC3=CC=C(C=C3)O
• IUPAC Name: 4-[(E)-2-[4-[(E)-2-(4-hydroxyphenyl)ethenyl]-3-methoxyphenyl]ethenyl]phenol
• InChIKey: FGYNZFHVGOFCMD-KHVHPYDTSA-N
• INCHI: 1S/C23H20O3/c1-26-23-16-19(3-2-17-6-12-21(24)13-7-17)5-11-20(23)10-4-18-8-14-22(25)15-9-18/h2-16,24-25H,1H3/b3-2+,10-4+
• SMILES isoméricas: COC1=C(C=CC(=C1)/C=C/C2=CC=C(C=C2)O)/C=C/C3=CC=C(C=C3)O
• Peso molecular: 344.4
• Reaxy-Rn: 18678256
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18678256&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Classe Stilbenes

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Classe: Stilbenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Stilbenes
• Alternative Parents: Styrenes Phenoxy compounds Methoxybenzenes Anisoles Alkyl aryl ethers 1-hydroxy-2-unsubstituted benzenoids Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Stilbene - Phenoxy compound - Anisole - Methoxybenzene - Styrene - Phenol ether - 1-hydroxy-2-unsubstituted benzenoid - Alkyl aryl ether - Phenol - Benzenoid - Monocyclic benzene moiety - Ether - Organooxygen compound - Hydrocarbon derivative - Organic oxygen compound - Aromatic homomonocyclic compound
• Descrição: This compound belongs to the class of organic compounds known as stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

APP Tclin Amyloid-beta A4 protein (1 Activities)

Discover Target: APP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPT Tclin Microtubule-associated protein tau (2 Activities)

Discover Target: MAPT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APP Tclin Amyloid-beta A4 protein (8510 Activities)

Discover Target: APP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Alvos associados (não humanos)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: Soluble in DMSO to 100 mM and in ethanol to 20 mM
• Peso molecular: 344.400 g/mol
• XLogP3: 5.700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 344.141 Da
• Monoisotopic Mass: 344.141 Da
• Topological Polar Surface Area: 49.700 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 456.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 1

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥97% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 863918-78-9, the molecular formula is C23H20O3, and the molecular weight is 344.4 g/mol. InChIKey FGYNZFHVGOFCMD-KHVHPYDTSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.