Methscopolamine - 10mM in DMSO , Muscarinic acetylcholine receptor M1 antagonist, CAS No.155-41-9, Muscarinic acetylcholine receptor M1 antagonist

CAS: 155-41-9 Cat. No.: M408775 Fórmula: C₁₈H₂₄BrNO₄ Peso molecular: 398.29 Número CE: 205-844-5 PubChem CID: 5459110

GRADE & PURITY 10mM in DMSO

Synonyms

(1α,​2β,​4β,​5α,​7β)​-7-​[(2S)​-​3-​hydroxy-​1-​oxo-​2-​phenylpropoxy]​-​9,​9-​dimethyl-3-​oxa-​9-​azoniatricyclo[3.3.1​.02,​4]​nonane, bromide (1:1)​

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Methscopolamine is a muscarinic acetylcholine receptor blocker.
In vitro

In vivo

Cell Data

cell lines：A375, 22RV1 and T474 cells

Concentrations：

Incubation Time：

Powder Purity:≥95%

Specifications

Sinónimos

(1α,​2β,​4β,​5α,​7β)​-7-​[(2S)​-​3-​hydroxy-​1-​oxo-​2-​phenylpropoxy]​-​9,​9-​dimethyl-3-​oxa-​9-​azoniatricyclo[3.3.1​.02,​4]​nonane, bromide (1:1)​

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Methscopolamine is a muscarinic acetylcholine receptor blocker.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

ANTAGONIST

Mecanismo de ação

Muscarinic acetylcholine receptor M1 antagonist

Nomes e identificadores

• SMILES isoméricas: C[N+]1([C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)[C@H](CO)C4=CC=CC=C4)C.[Br-]
• PubChem CID: 5459110
• Peso molecular: 398.29

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 30 mg/mL (100.21 mM); Water: Insoluble; Ethanol: Insoluble
• Rotação específica [α]: -24°C

Referências

1. Song Changgeng, Zhao Yan, Zhang Jiajia, Dong Ziyi, Kang Xin, Pan Yuqi, Du Jinle, Gao Yiting, Zhang Haifeng, Xi Ye, Ding Hui, Kuang Fang, Wang Wenting, Luo Ceng, Zhang Zhengping, Zhao Qinpeng, Yang Jiazhou, Jiang Wen, Wu Shengxi, Gao Fang.  (2023)  Spatial Distribution of Parvalbumin-Positive Fibers in the Mouse Brain and Their Alterations in Mouse Models of Temporal Lobe Epilepsy and Parkinson’s Disease.  Neuroscience Bulletin,      [PMID:37523099] [10.1007/s12264-023-01083-0]

2. Song Changgeng, Zhao Jingjing, Hao Jianmin, Mi Dan, Zhang Jiajia, Liu Yingying, Wu Shengxi, Gao Fang, Jiang Wen.  (2023)  Aminoprocalcitonin protects against hippocampal neuronal death via preserving oxidative phosphorylation in refractory status epilepticus.  Cell Death Discovery,  9  (1): (1-18).  [PMID:37142587] [10.1038/s41420-023-01445-7]

3. Fankai Gao, Rui Chen, Shuo Li, An Li, Bo Bai, Rulin Mi, Guofang Xue.  (2023)  (+)-Borneol exerts neuroprotective effects via suppressing the NF-κB pathway in the pilocarpine-induced epileptogenesis rat model.  BRAIN RESEARCH,      [PMID:37127175] [10.1016/j.brainres.2023.148382]

4. Huijie Huangfu, Xugeng Guo, Ning Li, Ye Xiong, Yafei Huang, Jinglai Zhang, Li Wang.  (2023)  A smart composite coating with self-reporting and self-healing functions to enhance corrosion protection for magnesium alloys.  PROGRESS IN ORGANIC COATINGS,      [PMID:] [10.1016/j.porgcoat.2023.107598]

5. Dai Jie, Shen Hai-lin, Li Jia, Zhou Yong, Dong Zheng-xie, Zhu Xiang-yang.  (2024)  Gastrodin Attenuates Neuroinflammation and Injury in Young Rats with LiCl/Pilocarpine-Induced Status Epilepticus.  BIOCHEMICAL GENETICS,      [PMID:39570508] [10.1007/s10528-024-10971-7]

6. Yang Yu, Li Xingchang, Gong Shuxian, Sui Lisen, Liu Jian, Yu Fangjun, Zhang Tianpeng.  (2025)  E4BP4-Driven Circadian SLC6A1 Expression Governs Tiagabine Chronoefficacy in Temporal Lobe Epilepsy.  MOLECULAR NEUROBIOLOGY,  63  (1): (242).  [PMID:41335220] [10.1007/s12035-025-05498-w]