ML133 HCl - 10mM in DMSO , CAS No.1222781-70-5

CAS: 1222781-70-5 Cat. No.: M409030 Fórmula: C₁₉H₁₉NO.HCl Peso molecular: 313.82 Número CE: 694-462-6

GRADE & PURITY 10mM in DMSO

Synonyms

1-Naphthalenemethanamine, N-[(4-methoxyphenyl)methyl]-, hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

ML133 HCl ML133 HCl is a selective potassium channel inhibitor for K ir 2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on K ir 1.1 and weak activity for K ir 4.1 and K ir 7.1.
In vitro

The ratio of total concentration of extracellular ML133 versus intracellular ML133 is 1:0.13 at pH 6.5, 1:9.09 at pH 8.5. ML133 is clean against 3A4 and 2C9 (IC50 >30 μM), displays moderate inhibition of 1A2 (IC50 = 3.3 μM) but proves to be a potent inhibitor of 2D6 (IC50 = 0.13 μM) in CYP450 assay. ML133 is highly protein bound (>99%) in both human and rat and also displays high intrinsic clearance in both species. ML133 (10 μM) is not displaced by K⁺ influx from the wild-type K_ir2.1 in HEK 293 cells. M1 and/or M2 transmembrane domains contain the critical molecular determinant for ML133 inhibition of K_ir2.1, especially D172 and I176.

In vivo

Cell Data

cell lines：HCT116 and U87MG cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

1-Naphthalenemethanamine, N-[(4-methoxyphenyl)methyl]-, hydrochloride (1:1)

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

ML133 HCl is a selective potassium channel inhibitor for K_ir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on K_ir1.1 and weak activity for K_ir4.1 and K_ir7.1.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Nomes e identificadores

• SMILES isoméricas: COC1=CC=C(C=C1)CNCC2=CC=CC3=CC=CC=C32.Cl
• WGK Alemanha: 3
• Peso molecular: 313.82
• Reaxy-Rn: 40757246
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=40757246&ln=

Perguntas frequentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1222781-70-5, the molecular formula is C19H20ClNO, and the molecular weight is 313.82 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.