MLT-748 - ≥99% , CAS No.1832578-30-9

CAS: 1832578-30-9 Cat. No.: M414254 Fórmula: C₁₉H₁₉Cl₂N₉O₃ Peso molecular: 492.32 PubChem CID: 129072285

GRAU & PUREZA ≥99%

Synonyms

Urea,N-​[2-​chloro-​7-​[(1R,​2R)​-​1,​2-​dimethoxypropyl]​pyrazolo[1,​5-​a]​pyrimidin-​6-​yl]​-​N'-​[5-​chloro-​6-​(2H-​1,​2,​3-​triazol-​2-​yl)​-​3-​pyridinyl]​-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Information

MLT-748 MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state.

Targets

MALT1 (Cell-free assay) 5 nM

In vitro

MLT-748 binds MALT1 in the allosteric Trp580 pocket. MLT-748 binds and stabilizes mutant MALT1-W580S. Cleavage of MALT1 substrates is blocked by MLT-748 in B and T cells. MLT-748 rescues MALT1 function in patient MALT1^mut/mut lymphocytes.

Cell Research(from reference)

Cell lines：Immortalized B cells, human PBMCs, primary human CD3+ T cells, primary CD4+ lymphocytes 

Concentrations：2 μM 

Incubation Time：24 h 

Especificações

Sinónimos

Urea,N-​[2-​chloro-​7-​[(1R,​2R)​-​1,​2-​dimethoxypropyl]​pyrazolo[1,​5-​a]​pyrimidin-​6-​yl]​-​N'-​[5-​chloro-​6-​(2H-​1,​2,​3-​triazol-​2-​yl)​-​3-​pyridinyl]​-

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Pureza

≥99%

Nomes e identificadores

Pubchem Sid

528765543

Sorrisos canónicos

CC(C(C1=C(C=NC2=CC(=NN21)Cl)NC(=O)NC3=CC(=C(N=C3)N4N=CC=N4)Cl)OC)OC

IUPAC Name

1-[2-chloro-7-[(1R,2R)-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-[5-chloro-6-(triazol-2-yl)pyridin-3-yl]urea

InChIKey

XKQLNDPUQSZBJW-QGHHPUGFSA-N

INCHI

1S/C19H19Cl2N9O3/c1-10(32-2)17(33-3)16-13(9-22-15-7-14(21)28-29(15)16)27-19(31)26-11-6-12(20)18(23-8-11)30-24-4-5-25-30/h4-10,17H,1-3H3,(H2,26,27,31)/t10-,17+/m1/s1

PubChem CID

129072285

Peso molecular

492.32

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Pyridines and derivatives
      • Subclass Pyridyltriazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Pyridines and derivatives
• Subclass: Pyridyltriazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyridyl-1,2,3-triazoles
• Alternative Parents: Pyrazolo[1,5-a]pyrimidines Pyrimidines and pyrimidine derivatives Aryl chlorides Triazoles Pyrazoles Heteroaromatic compounds Ureas Dialkyl ethers Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Pyridyl-1,2,3-triazole - Pyrazolo[1,5-a]pyrimidine - Pyrazolopyrimidine - Pyrimidine - Aryl halide - Aryl chloride - Heteroaromatic compound - 1,2,3-triazole - Triazole - Pyrazole - Azole - Urea - Carbonic acid derivative - Azacycle - Ether - Dialkyl ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Carbonyl group - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as pyridyl-1,2,3-triazoles. These are organic compounds containing a pyridine ring attached to a 1,2,3-triazole ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 98 mg/mL (199.05 mM); Ethanol: 10 mg/mL (20.31 mM); Water: Insoluble
• Peso molecular: 492.300 g/mol
• XLogP3: 1.700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 491.099 Da
• Monoisotopic Mass: 491.099 Da
• Topological Polar Surface Area: 133.000 Ų
• Heavy Atom Count: 33
• Formal Charge: 0
• Complexity: 662.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1