MMAF-d8hydrochloride - ≥99% , CAS No.M658677

CAS: M658677 Cat. No.: M658677 Fórmula: C₃₉H₅₈D₈ClN₅O₈ Peso molecular: 776.47

GRAU & PUREZA ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Visão geral

MMAF-d 8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.

Appearance:Solid

IC50& Target:Auristatin

In Vitro:MMAF shows in vitro cytotoxicity against a panel of cell lines. The IC 50 values for Karpas 299, H3396, 786-O and Caki-1 are 119, 105, 257, and 200 nM, respectively. Targeted MMAF is much more potent than the free drug, and that cAC10 conjugates of MMAF d

In Vivo:The maximum tolerated dose in mice of MMAF (>16mg/kg) is much higher than MMAE (1mg/kg). cAC10-L1-MMAF 4 has an MTD of 50mg/kg in mice and 15mg/kg in rats. The corresponding cAC10-L4-MMAF 4 ADC was much less toxic, having MTDs in mice and rats of >150

Biological Activity:MMAF-d 8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.

Especificações

Especificações e pureza

≥99%

Condições de armazenamento de armazenamento

Store at 2-8°C,Desiccated

Enviado em

Wet ice

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥99%

Nomes e identificadores

Sorrisos canónicos

O=C(O)[C@H](CC1=CC=CC=C1)NC([C@H](C)[C@@H](OC)[C@H]2N(C(C[C@@H](OC)[C@@H](N(C)C([C@@]([2H])(NC([C@@H](NC)C(C)C)=O)C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)[C@@H](C)CC)=O)CCC2)=O.Cl

Peso molecular

776.47

Propriedades químicas e físicas

• Solubilidade: DMSO : 100 mg/mL (128.79 mM; Need ultrasonic)

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is M658677, the molecular formula is C39H58D8ClN5O8, and the molecular weight is 776.47 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.