MS48107 - 10mM in DMSO , CAS No.2375070-79-2

CAS: 2375070-79-2 Cat. No.: M654764 Fórmula: C₂₃H₂₀FN₅O₂ Peso molecular: 417.44 PubChem CID: 139030523

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

MS48107 is a potent and selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68). MS48107 is selective for GPR68 over the closely related proton GPCRs, neurotransmitter transporters, and hERG ion channels. MS48107 can readily cross the blood-brain barrier (BBB) in mice.

In Vitro

5-HT2B has moderate binding affinity to MS48107 (compound 71) with a K i value of 219 nM. At 5-HT2B receptors, MS48107 shows no agonist activity but display weak antagonist activity with a K i value of 310 nM, respectively. MS48107 (compound 71) has agonist activity only at the MT1 and MT2 receptors. MS48107 is a weak full agonist at the MT1 receptor (EC 50 = 320 nM) and a weak partial agonist activity at the MT2 receptor (EC 50 = 540 nM). MS48107 displays low binding affinities to MT1 (5900 nM) and MT2 (1100 nM) receptors. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

For MS48107 (compound 71), a single intraperitoneal injection at the dose of 25 mg/kg leads to high exposure levels (above 10 μM) in both plasma and brain at 0.5 h in mice (Swiss Albino mice). The high compound exposure levels in both plasma and brain are maintained for 2 h . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

MS48107 is a potent and selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68) . MS48107 is selective for GPR68 over the closely related proton GPCRs, neurotransmitter transporters, and hERG ion channels. MS48107 can readily cros

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Nomes e identificadores

• SMILES isoméricas: C1=CC=C(C=C1)OC2=CC=C(C=C2)CNC3=NC(=NC(=N3)N)C4=C(C=CC=C4F)CO
• PubChem CID: 139030523
• Peso molecular: 417.44

Perguntas frequentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2375070-79-2, the molecular formula is C23H20FN5O2, and the molecular weight is 417.44 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.