MYF-01-37 - ≥98% , CAS No.2416417-65-5

CAS: 2416417-65-5 Cat. No.: M414290 Fórmula: C₁₅H₁₇F₃N₂O Peso molecular: 298.3

GRADE & PURITY ≥98%

Synonyms

1-(3-(3-(trifluoromethyl)phenylamino)-3-methylpyrrolidin-1-yl)prop-2-en-1-one

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Information

MYF-01-37 MYF-01-37 is a novel covalent inhibitor of TEAD targeting Cys380 when incubated with the TEAD2 protein.

Targets

TEAD

In vitro

MYF-01-37 is developed as a covalent binder to TEAD, targeting Cys380 when incubated with the TEAD2 protein (C359 in TEAD1). Pretreating cells with MYF-01-37 leads to loss of direct TEAD pull-down by biotin-MYF-01-037 from whole-cell lysate, confirming MYF-01-037 binding to TEAD in cells.

Cell Research(from reference)

Cell lines：PC9 cells 

Concentrations：10 μM, 1 μM 

Incubation Time：6 h 

Specifications

Sinónimos

1-(3-(3-(trifluoromethyl)phenylamino)-3-methylpyrrolidin-1-yl)prop-2-en-1-one

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

MYF-01-37 is a novel covalent inhibitor of TEAD targeting Cys380 when incubated with the TEAD2 protein.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥98%

Nomes e identificadores

Pubchem Sid

504773627

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504773627

Sorrisos canónicos

CC1(CCN(C1)C(=O)C=C)NC2=CC=CC(=C2)C(F)(F)F

IUPAC Name

1-[3-methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one

InChIKey

MTBDEVWWJBIUOK-UHFFFAOYSA-N

INCHI

1S/C15H17F3N2O/c1-3-13(21)20-8-7-14(2,10-20)19-12-6-4-5-11(9-12)15(16,17)18/h3-6,9,19H,1,7-8,10H2,2H3

Peso molecular

298.3

Reaxy-Rn

36048179

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=36048179&ln=

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 60 mg/mL (201.13 mM); Ethanol: 60 mg/mL (201.13 mM); Water: Insoluble
• Peso molecular: 298.300 g/mol
• XLogP3: 3.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 298.129 Da
• Monoisotopic Mass: 298.129 Da
• Topological Polar Surface Area: 32.299 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 410.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2416417-65-5, the molecular formula is C15H17F3N2O, and the molecular weight is 298.3 g/mol. InChIKey MTBDEVWWJBIUOK-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.