Neoantimycin - ≥95% , CAS No.22862-63-1

CAS: 22862-63-1 Cat. No.: N329566 Fórmula: C₃₆H₄₆N₂O₁₂ Peso molecular: 698.76

GRAU & PUREZA ≥95%

Synonyms

1,4,8,11-Tetraoxacyclopentadecane, neoantimycin deriv. | 3-(Formylamino)-2-hydroxy-N-[(3S,6S,7R,10S,14R,15R)-14-hydroxy-7,13,13-trimethyl-3-(1-methylethyl)-10-[(1S)-1-methylpropyl]-2,5,9,12-tetraoxo-15-(phenylmethyl)-1,4,8,11-tetraoxacyclopentadec-6-yl]be

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Neoantimycin is a macrocyclic antibiotic isolated from|Streptomyces|bacteria. The mechanism of action of Neoantimycin is undescribed in the literature. A closely related compound described as an oxidized-type neoantimycin, prunustatin A, is demonstrated to downregulate grp78 transcription and suppress the expression of the GRP 78 molecular chaperone. This suppression affects the role of GRP 78 in promoting protein folding at the endoplasmic reticulum (ER), and suppresses the pro-resistance enhancement of ER stress response by chemotherapy-resistant tumors. The close structural kinship between prunustatin A and Neoantimycin suggests a similar mechanism of action for Neoantimycin toxicity.

Especificações

Sinónimos

1,4,8,11-Tetraoxacyclopentadecane, neoantimycin deriv. | 3-(Formylamino)-2-hydroxy-N-[(3S,6S,7R,10S,14R,15R)-14-hydroxy-7,13,13-trimethyl-3-(1-methylethyl)-10-[(1S)-1-methylpropyl]-2,5,9,12-tetraoxo-15-(phenylmethyl)-1,4,8,11-tetraoxacyclopentadec-6-yl]be

Especificações e pureza

≥95%

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥95%

Nomes e identificadores

Pubchem Sid

528771978

Sorrisos canónicos

CCC(C)C1C(=O)OC(C(C(=O)OC(C(=O)OC(C(C(C(=O)O1)(C)C)O)CC2=CC=CC=C2)C(C)C)NC(=O)C3=C(C(=CC=C3)NC=O)O)C

IUPAC Name

N-(15-benzyl-10-butan-2-yl-14-hydroxy-7,13,13-trimethyl-2,5,9,12-tetraoxo-3-propan-2-yl-1,4,8,11-tetraoxacyclopentadec-6-yl)-3-formamido-2-hydroxybenzamide

InChIKey

JIJATTFJYJZEBT-UHFFFAOYSA-N

INCHI

1S/C36H46N2O12/c1-8-20(4)29-34(45)47-21(5)26(38-31(42)23-15-12-16-24(27(23)40)37-18-39)32(43)49-28(19(2)3)33(44)48-25(17-22-13-10-9-11-14-22)30(41)36(6,7)35(46)50-29/h9-16,18-21,25-26,28-30,40-41H,8,17H2,1-7H3,(H,37,39)(H,38,42)

SMILES isoméricas

CCC(C)C1C(=O)OC(C(C(=O)OC(C(=O)OC(C(C(C(=O)O1)(C)C)O)CC2=CC=CC=C2)C(C)C)NC(=O)C3=C(C(=CC=C3)NC=O)O)C

Peso molecular

698.76

Reaxy-Rn

3116939

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3116939&ln=

Propriedades químicas e físicas

• Solubilidade: Soluble in ethanol, methanol, DMF, and DMSO.
• Índice de refração: n20D1.58 (Predicted)
• Ponto de ebulição (°C): 930.35° C at 760 mmHg (Predicted)