NRD167 , CAS No.2166487-23-4

CAS: 2166487-23-4 Cat. No.: N419999

Synonyms

Ethyl-(5S,8S)-5-((1H-indol-3-yl)methyl)-8-(((benzyloxy)carbonyl)amino)-2-methyl-4,7-dioxo-14-thioxo-3,6,13,15-tetraazaoctadecan-18-oate | Et-29

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Visão geral

Sequence:Z-Lys(thiourea-beta-Ala-OEt)-Trp-Isopropylamine

Specifications

Sinónimos

Ethyl-(5S,8S)-5-((1H-indol-3-yl)methyl)-8-(((benzyloxy)carbonyl)amino)-2-methyl-4,7-dioxo-14-thioxo-3,6,13,15-tetraazaoctadecan-18-oate | Et-29

Mecanismos bioquímicos e fisiológicos

RD167 is the ethylester prodrug of a potent and selective sirtuin 5 (SIRT5) inhibitor (IC50 = 370 nM; <10% inhibition of SIRT1/2/3/6 at 10 μM). NRD167 exhibits anti-proliferation (IC50 = 5-8 μM) and apoptosis-induction efficacy (>80% at 5-8 μM) against SI

Condições de armazenamento de armazenamento

Protected from light,Store at -20°C,Argon charged

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Propriedades químicas e físicas

• Solubilidade: DMSO: 2 mg/mL, clear
• Sensibilidade: Light sensitive

Referências

1. Zekun Liu, Jie Hu, Yinan Lin, Chuang Ge, Yuru Shao, Mengmeng Bao, Mengjie Liu, Shilin Jia, Yating Li, Xiaozhi Xu, Ruiyan Li, Qizhou Jiang, Fangrong Yan, Fei Xiao, Junmei Ye.  (2025)  SIRT5 Facilitates Liver Steatosis Progression via Promoting SDH Desuccinylation During High-Fat Diet Feeding.  LIVER INTERNATIONAL,  45  (12): (e70433).  [PMID:41221659] [10.1111/liv.70433]