Nutlin-3a - ≥97% , CAS No.675576-98-4

CAS: 675576-98-4 Cat. No.: N129972 Fórmula: C30H30Cl2N4O4 Peso molecular: 581.49 Número CE: 809-614-0
Disponível para encomenda
GRAU & PUREZA ≥97%
Synonyms
(-)-Nutlin-3 | Nutlin-3a, >=98% (HPLC) | REBEMADLIN [INN] | Z2037279564 | (-)-4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one | SML-0580 | AKOS027422740 | 2-Piperazinone, 4-(((4S,5R)-4,5-bis(
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
Tamanho
Alemanha (EU)
USA*
Preço
Qtd
5mg
N129972-5mg
—
2 Em stock

60,65€

91,03€
Gravar 30,37 € (33.37%)
25mg
N129972-25mg
—
2 Em stock

224,66€

337,46€
Gravar 112,81 € (33.43%)
50mg
N129972-50mg
—
3 Em stock

381,72€

572,62€
Gravar 190,90 € (33.34%)
Enter a quantity for the sizes you want to add.
🧪
Por que este grau

≥97% para fluxos de trabalho cromatográficos e analíticos sensíveis que exigem interferência mínima da linha de base.

🌡

Armazenamento e envio

Store at -20°C Envio Ice chest + Ice pads. Consulte o COA específico do lote para obter as especificações exatas.

📋

Documentos de qualidade

SDS, COA, ficha técnica e folha de especificações disponíveis para download. COA específico do lote acessível por meio de pesquisa por número de lote.

📚

Comprovação documental

Citado em 2 publicações revisadas por pares nas áreas de cromatografia, síntese orgânica e reações de acoplamento cruzado.

Especificações

Sinónimos
(-)-Nutlin-3 | Nutlin-3a, >=98% (HPLC) | REBEMADLIN [INN] | Z2037279564 | (-)-4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one | SML-0580 | AKOS027422740 | 2-Piperazinone, 4-(((4S,5R)-4,5-bis(
Especificações e pureza
≥97%
Mecanismos bioquímicos e fisiológicos
Nutlin-3a [(-)-Nutlin] is a more potent diasteromer of nutlin-3, a racemic MDM2 antagonist. It is called enantiomer A because it will serve as the first peak elution of racemic Nutlin-3 chiral purification. Nutlin-3a is a potent inhibitor of MDM2 (murine
Condições de armazenamento de armazenamento
Store at -20°C
Enviado em
Ice chest + Ice pads
Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.
Tipo de ação
INHIBITOR
Nota
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Pureza
≥97%
Nomes e identificadores
Pubchem Sid
Pubchem Sid Url
https://pubchem.ncbi.nlm.nih.gov/substance/504766412
Sorrisos canónicos
CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
IUPAC Name
4-[(4S,5R)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
InChIKey
BDUHCSBCVGXTJM-WUFINQPMSA-N
INCHI
1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1
SMILES isoméricas
CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
WGK Alemanha
3
Peso molecular
581.49
Reaxy-Rn
11322582
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11322582&ln=

Documentação

📋 Ficha de dados de segurança (FDS)

Documento abrangente sobre perigos, manuseamento, armazenamento e conformidade regulamentar.

<<<<<<< HEAD Baixar SDS → ======= Baixar SDS → >>>>>>> release248-p3

✅ Certificado de análise (COA)

Dados de qualidade específicos do lote. Introduza o número de lote para obter o COA exato.

Consultar COA →

📊 Ficha técnica

Resumo de referência rápida das especificações e aplicações do produto.

Ver ficha técnica →

🔬 Folha de especificações

Atributos de qualidade completos e critérios de aceitação para este grau.

Ver folha de especificações →

Dados avançados

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassPhenylpropanoids and polyketides
ClasseStilbenes
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentStilbenes
Alternative Parents Alpha amino acids and derivatives  Piperazine carboxamides  Phenoxy compounds  Anisoles  Methoxybenzenes  Alkyl aryl ethers  Chlorobenzenes  Aryl chlorides  Imidazolines  Ureas  Secondary carboxylic acid amides  Lactams  Propargyl-type 1,3-dipolar organic compounds  Carboximidamides  Carboxamidines  Azacyclic compounds  Carbonyl compounds  Hydrocarbon derivatives  Organic oxides  Organochlorides  Organopnictogen compounds  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents Stilbene - Alpha-amino acid or derivatives - Piperazine-1-carboxamide - Phenoxy compound - Anisole - Phenol ether - Methoxybenzene - Alkyl aryl ether - Halobenzene - Chlorobenzene - Aryl chloride - Aryl halide - Piperazine - Monocyclic benzene moiety - Benzenoid - 1,4-diazinane - 2-imidazoline - Secondary carboxylic acid amide - Carbonic acid derivative - Urea - Carboxamide group - Lactam - Amidine - Azacycle - Carboxylic acid amidine - Organoheterocyclic compound - Carboxylic acid derivative - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Ether - Carboximidamide - Organopnictogen compound - Organic nitrogen compound - Organic oxide - Hydrocarbon derivative - Organic oxygen compound - Carbonyl group - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Aromatic heteromonocyclic compound
DescriçãoThis compound belongs to the class of organic compounds known as stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids.
External Descriptors Not available
Estrutura 3D
Modelo de Estrutura Química Interativa





Alvos associados (humanos)
MDM2 Tchem E3 ubiquitin-protein ligase Mdm2 (31 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TP53 Tchem Cellular tumor antigen p53 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDM2 Tchem p53-binding protein Mdm-2 (4545 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
5637 (630 Activities)
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A 172 (535 Activities)
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A204 (242 Activities)
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A2058 (690 Activities)
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A-375 (9258 Activities)
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A673 (619 Activities)
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ACHN (49357 Activities)
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AGS (1999 Activities)
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BT-20 (503 Activities)
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BT-474 (2113 Activities)
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BXPC-3 (2997 Activities)
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C8166 (1658 Activities)
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Caco-2 (12174 Activities)
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CAKI-1 (44928 Activities)
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CAPAN-1 (772 Activities)
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CCRF-CEM (65223 Activities)
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CFPAC-1 (421 Activities)
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DMS-273 (14108 Activities)
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DU-145 (51482 Activities)
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G-401 (156 Activities)
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HL-60 (67320 Activities)
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HT-1080 (3966 Activities)
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HT-29 (80576 Activities)
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Huh-7 (12904 Activities)
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K562 (73714 Activities)
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KM12 (47707 Activities)
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M14 (47487 Activities)
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MCF7 (126967 Activities)
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MDA-MB-361 (612 Activities)
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MDA-MB-453 (1139 Activities)
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MG-63 (795 Activities)
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MKN-1 (175 Activities)
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MKN-28 (466 Activities)
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MKN-45 (2102 Activities)
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MKN-7 (272 Activities)
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ML-2 (146 Activities)
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MOLT-4 (49676 Activities)
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Alvos associados (não humanos)
Hdac1 Histone deacetylase 1 (93 Activities)
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Saccharomyces cerevisiae (19171 Activities)
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Mus musculus (284745 Activities)
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Vero (26788 Activities)
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H4 (48 Activities)
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Brain (1 Activities)
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Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lung (9 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bone marrow (11 Activities)
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Intestine (514 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Muscle (539 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Spleen (906 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDM2 E3 ubiquitin-protein ligase Mdm2 (2 Activities)
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Mecanismos de ação
Certificados(CoA,COO,BSE/TSE e Mapa de Análise)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot NumberCertificate TypeDataItem
L2420453L2420453Certificate of AnalysisSep 21, 2026 N129972
I2222781I2222781Certificate of AnalysisJul 23, 2022 N129972
I2222782I2222782Certificate of AnalysisJul 23, 2022 N129972
I2222796I2222796Certificate of AnalysisJul 23, 2022 N129972
Propriedades químicas e físicas
SolubilidadeDMSO 100 mg/mL Water <1 mg/mL Ethanol 100 mg/mL
Rotação específica [α][α]/D -130 to -154° (c=0.5, CDCl3)
Peso molecular581.500 g/mol
XLogP35.200
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass580.164 Da
Monoisotopic Mass580.164 Da
Topological Polar Surface Area83.500 Ų
Heavy Atom Count40
Formal Charge0
Complexity919.000
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
FAQs e artigos
Citations of This Product
Calculadoras de soluções
Revisões

Avaliações dos Clientes

Perguntas frequentes

What is the purity of this product?
This product is supplied at ≥97% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 675576-98-4, the molecular formula is C30H30Cl2N4O4, and the molecular weight is 581.49 g/mol. InChIKey BDUHCSBCVGXTJM-WUFINQPMSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

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