NYX-2925 - Moligand™ , Allosteric modulator of GluN2A, CAS No.N612447, Allosteric modulator of GluN2A

CAS: N612447 Cat. No.: N612447 PubChem CID: 122594417

GRADE & PURITY Moligand™

Synonyms

2012536-16-0 | NYX2925 | NYX-2925 | 2,5-DIAZASPIRO(3.4)OCTANE-2-ACETAMIDE, .ALPHA.-((1R)-1-HYDROXYETHYL)-5-(2-METHYL-1-OXOPROPYL)-1-OXO-, (.ALPHA.S,4R)- | (2S,3R)-3-hydroxy-2-[(4R)-5-(2-methylpropanoyl)-3-oxo-2,5-diazaspiro[3.4]octan-2-yl]butanamide | X06

Storage

Room temperature

Specifications

Synonyms

2012536-16-0 | NYX2925 | NYX-2925 | 2, 5-DIAZASPIRO(3.4)OCTANE-2-ACETAMIDE, .ALPHA.-((1R)-1-HYDROXYETHYL)-5-(2-METHYL-1-OXOPROPYL)-1-OXO-, (.ALPHA.S, 4R)- | (2S, 3R)-3-hydroxy-2-[(4R)-5-(2-methylpropanoyl)-3-oxo-2, 5-diazaspiro[3.4]octan-2-yl]butanamide | X06

Specifications & Purity

Moligand™

Storage

Room temperature

Grade

Moligand™

Action Type

ALLOSTERIC MODULATOR

Mechanism of action

Allosteric modulator of GluN2A

Names and Identifiers

• Canonical Smiles: CC(C(=O)N1CCC[C@@]21CN(C2=O)[C@H](C(=O)N)[C@H](O)C)C
• IUPAC Name: (2S,3R)-3-hydroxy-2-[(4R)-5-(2-methylpropanoyl)-3-oxo-2,5-diazaspiro[3.4]octan-2-yl]butanamide
• InChIKey: NFXPEHLDVKVVKA-ISTVAULSSA-N
• INCHI: 1S/C14H23N3O4/c1-8(2)12(20)17-6-4-5-14(17)7-16(13(14)21)10(9(3)18)11(15)19/h8-10,18H,4-7H2,1-3H3,(H2,15,19)/t9-,10+,14-/m1/s1
• Isomeric SMILES: C[C@H]([C@@H](C(=O)N)N1C[C@@]2(C1=O)CCCN2C(=O)C(C)C)O
• PubChem CID: 122594417

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Dipeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Dipeptides
• Alternative Parents: Alpha amino acids and derivatives Pyrrolidinecarboxamides N-acylpyrrolidines N-acyl amines Tertiary carboxylic acid amides Beta lactams Secondary alcohols Azetidines Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic heteropolycyclic compounds
• Substituents: Alpha-dipeptide - Alpha-amino acid or derivatives - Pyrrolidine-2-carboxamide - Pyrrolidine carboxylic acid or derivatives - N-acylpyrrolidine - Fatty acyl - N-acyl-amine - Fatty amide - Tertiary carboxylic acid amide - Pyrrolidine - Beta-lactam - Secondary alcohol - Lactam - Carboxamide group - Azetidine - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Alcohol - Aliphatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

GRIN2A Tclin Glutamate receptor ionotropic, NMDA 2A (0 Activities)

Discover Target: GRIN2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)