Ochromycinone (STA-21) - ≥98% , CAS No.111540-00-2

Name: Ochromycinone (STA-21) - ≥98% , CAS No.111540-00-2
SKU: O413885
Availability: InStock

CAS: 111540-00-2 Cat. No.: O413885 Fórmula: C₁₉H₁₄O₄ Peso molecular: 306.31

COA

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Ochromycinone (STA-21) - ≥98% CAS No(111540-00-2) by Aladdin Scientific

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Disponível para encomenda

GRADE & PURITY ≥98%

Synonyms

HY-18061 | NSC628869 | NSC-628869 | 8-hydroxy-3-methyl-3,4-dihydrotetraphene-1,7,12(2H)-trione | AKOS032945165 | Benz[a]anthracene-1,12-trione, 1,2,3,4,7,12-hexahydro-8-hydroxy-3-methyl- | FT-0673176 | CCG-267534 | {Benz[a]anthracene-1,7,12-trione,} 1,2,3

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral Specifications Nomes e identificadores Documentation Advanced Data Taxonomic Classification Estrutura 3D Alvos associados (humanos) Mecanismos de ação Certificados（CoA,COO,BSE/TSE e Mapa de Análise) Propriedades químicas e físicas FAQs e artigos Calculadoras de soluções Revisões Perguntas frequentes

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

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Application：

STA-21 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor to study its effects on glioblastoma and primary glioblastoma cells. It has also been used as a STAT3 dimerization inhibitor to study its effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) production in human lung cancer cell line.

Information

Ochromycinone (STA-21) is a selectiveSTAT3inhibitor.

Targets

STAT3

In vitro

In cells, STA-21 inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity. STA-21 remarkably inhibits the growth and the survival of the breast carcinoma cells MDA-MB-231, MDA-MB-435s, and MDA-MB-468 that express persistently activated Stat3. In RH30 and RD2 cells, STA-21 also inhibits cell viability and growth and induced apoptosis through caspases 3, 8 and 9 pathways.

In vivo

In IL-1Ra–KO mice, STA-21 (0.5 mg/kg, i.p.) reduces the arthritis score and the incidence of arthritis by decreasing the proportion of Th17 cells and increasing the proportion of Treg cells expressing FoxP3.

Cell Research(from reference)

Cell lines：MDA-MB-231, MDA-MB-435s, MDA-MB-453, MDA-MB-468, MCF7, and Caov-3 cells

Concentrations：20 or 30 μM

Incubation Time：48 h

Specifications

Sinónimos

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

Ochromycinone (STA-21) is a selective STAT3 inhibitor.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Pureza

≥98%

Nomes e identificadores

Pubchem Sid

504758592

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504758592

Sorrisos canónicos

CC1CC2=C(C(=O)C1)C3=C(C=C2)C(=O)C4=C(C3=O)C=CC=C4O

IUPAC Name

8-hydroxy-3-methyl-3,4-dihydro-2H-benzo[a]anthracene-1,7,12-trione

InChIKey

ZAWXOCUFQSQDJS-UHFFFAOYSA-N

INCHI

1S/C19H14O4/c1-9-7-10-5-6-12-17(15(10)14(21)8-9)19(23)11-3-2-4-13(20)16(11)18(12)22/h2-6,9,20H,7-8H2,1H3

SMILES isoméricas

CC1CC2=C(C(=O)C1)C3=C(C=C2)C(=O)C4=C(C3=O)C=CC=C4O

Peso molecular

306.31

Reaxy-Rn

3121949

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3121949&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Classe Angucyclines

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Classe	Angucyclines
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Angucyclines
Alternative Parents	Anthraquinones Phenanthrenes and derivatives Tetralins Aryl alkyl ketones 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Vinylogous acids Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic homopolycyclic compounds
Substituents	Angucycline core - 9,10-anthraquinone - Anthraquinone - Anthracene - Phenanthrene - Tetralin - Aryl alkyl ketone - Aryl ketone - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Benzenoid - Vinylogous acid - Ketone - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Aromatic homopolycyclic compound
Descrição	This compound belongs to the class of organic compounds known as angucyclines. These are polyketides with a structure based on then benz[a]anthracene skeleton, with the particularity that the central ring of the anthracene moiety is a para-quinone.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estrutura 3D

Alvos associados (humanos)

A498 (42825 Activities)

Lot Number	Certificate Type	Data	Item
E2625134	Certificate of Analysis	Jun 04, 2026	O413885
F2507080	Certificate of Analysis	Jun 25, 2025	O413885
F2229515	Certificate of Analysis	Apr 03, 2025	O413885
F2229516	Certificate of Analysis	Apr 03, 2025	O413885
F2229517	Certificate of Analysis	Apr 03, 2025	O413885
F2229518	Certificate of Analysis	Jul 15, 2022	O413885
F2229001	Certificate of Analysis	Jun 05, 2022	O413885
F2229002	Certificate of Analysis	Jun 05, 2022	O413885
F2229003	Certificate of Analysis	Jun 05, 2022	O413885
F2229004	Certificate of Analysis	Jun 05, 2022	O413885

Solubilidade	Solubility (25°C) In vitro DMSO: 21 mg/mL (68.55 mM); Ethanol: 2 mg/mL (6.52 mM); Water: Insoluble;
Peso molecular	306.300 g/mol
XLogP3	3.600
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Exact Mass	306.089 Da
Monoisotopic Mass	306.089 Da
Topological Polar Surface Area	71.400 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	554.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Ochromycinone (STA-21) - ≥98% , CAS No.111540-00-2

Storage & shipping

Quality documents

Literature proof

Visão geral

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Avaliações dos Clientes

Perguntas frequentes

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