≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C,Argon charged,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Visão geral
OP-1074 is a pure antiestrogen and a selective ER degrader (PA-SERD) , shows specific antiestrogenic activity for ERα and ERβ , inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC 50 of 1.6 and 3.2 nM, respectively
In Vitro
OP-1074 (0-100 nM; 24 hours) inhibits MCF-7 cells and CAMA-1 cells proliferation with IC50 values of 6.3 and 9.2 nM, respectively. OP-1074 (100 nM; 24 hours) destabilizatizes ERα protein expression in MCF-7 and CAMA-1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MCF-7 cells, CAMA-1 cells Concentration: 0 nM, 10 nM,100 nM Incubation Time: 24 hours Result: Inhibited breast cancer cell proliferation. Western Blot AnalysisCell Line: MCF-7 cells, CAMA-1 cells Concentration: 100 nM Incubation Time: 24 hours Result: Downregulated ERα protein expression.
Form:Solid
IC50& Target:ERα ERβ
Specifications
Especificações e pureza
≥99%
Mecanismos bioquímicos e fisiológicos
OP-1074 is a pure antiestrogen and a selective ER degrader (PA-SERD) , shows specific antiestrogenic activity for ERα and ERβ , inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC 50 of 1.6 and 3.2u2009nM, respectively.
Condições de armazenamento de armazenamento
Store at -20°C,Argon charged,Desiccated
Enviado em
Ice chest + Ice pads
Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.
Tipo de ação
DEGRADER
Pureza
≥99%
Nomes e identificadores
Peso molecular
457.56
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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Revisões
Avaliações dos Clientes
Perguntas frequentes
What is the purity of this product?
This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
How should this product be stored?
Store at ?20 °C, desiccated, under argon. It is supplied under an argon blanket; reseal under inert gas after each use.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 1443752-76-8, the molecular formula is C29H31NO4, and the molecular weight is 457.56 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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