PD153035 HCl - ≥98%(HPLC) , CAS No.183322-45-4

CAS: 183322-45-4 Cat. No.: P129384 Fórmula: C₁₆H₁₄BrN₃O₂·HCl Peso molecular: 396.67 Número CE: 803-231-2

GRAU & PUREZA ≥98%(HPLC)

Synonyms

N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-aminium chloride|ZM252868|PD153035 HCl (SU-5271, AG1517)|PD153035 (Hydrochloride);SU-5271 (Hydrochloride); AG1517 (Hydrochloride); ZM 252868 (Hydrochloride)|ZM 252868 HCl|4,6,6-Trimethyl-2-mercapto-3,6-dihydropyrimidine|4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-, hydrochloride (1:1)|PD153035 (Hydrochloride)|SU 5271|(4-BROMO-2-FORMYLPHENOXY)ACETICACID|N-(3-Bromophenyl)-6,7-dimethoxy-4-quinazolinamine Hydrochloride|AG 1517 hydrochloride|PD153035.HCl|PD-153035.HCl|6,7-Dimethoxy-4-[N-(3-bromophenyl)amino]quinazoline hydrochloride|WHI-P-79 HYDROCHLORIDE|ZM 252868|PD153035 HCl|PD-153035 HCl|AG 1517|PD 153035 HYDROCHLORIDE|Diferaloylmethane|Tyrphostin AG 1517|4-QUINAZOLINAMINE, N-(3-BROMOPHENYL)-6,7-DIMETHOXY-, MONOHYDROCHLORIDE|AG-1517 HYDROCHLORIDE|N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride|N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-aminehydrochloride|PD153035 hydrochloride|PD-153035 hydrochloride|PD 153035.HCl|6,7-DIMETHOXY-4-(N-(3-BROMOPHENYL)AMINO)QUINAZOLINE HYDROCHLORIDE|4-[(3-BROMOPHENYL)AMINO]-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE|N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine;hydrochloride

Storage

Armazenar a -20°C

Shipped In

Arca de gelo + almofadas de gelo

Visão geral

O PD153035 é um inibidor potente e específico do EGFR com Ki e IC50 de 5,2 pM e 29 pM; pouco efeito observado contra PGDFR, FGFR, CSF-1, InsR e Src.
Um potente inibidor da tirosina quinase do recetor do fator de crescimento epidérmico (EGF)

Especificações

Sinónimos

N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-aminium chloride | ZM252868 | PD153035 HCl (SU-5271, AG1517) | PD153035 (Hydrochloride);SU-5271 (Hydrochloride); AG1517 (Hydrochloride); ZM 252868 (Hydrochloride) | ZM 252868 HCl | 4,6,6-Trimethyl-2-mercapto-3,6-dihydropyrimidine | 4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-, hydrochlori Show more

Especificações e pureza

≥98%(HPLC)

Mecanismos bioquímicos e fisiológicos

Um inibidor extremamente potente da tirosina quinase do recetor do fator de crescimento epidérmico (EGF), com um IC50 de 25 pM. Inibe outras tirosina-quinases purificadas apenas em concentrações micromolares ou superiores.

Condições de armazenamento de armazenamento

Armazenar a -20°C

Enviado em

Arca de gelo + almofadas de gelo

Tipo de ação

INHIBITOR

Pureza

≥98%(HPLC)

Nomes e identificadores

Pubchem Sid

528766557

Sorrisos canónicos

COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC.Cl

IUPAC Name

N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine;hydrochloride

InChIKey

ZJOKWAWPAPMNIM-UHFFFAOYSA-N

INCHI

1S/C16H14BrN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H

SMILES isoméricas

COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC.Cl

WGK Alemanha

3

Peso molecular

396.67

Reaxy-Rn

7400679

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7400679&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Diazanaphthalenes
      • Subclass Benzodiazines
        • Level5 Quinazolines
          • Level6 Quinazolinamines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Diazanaphthalenes
• Subclass: Benzodiazines
• Intermediate Tree Nodes: Quinazolines
• Direct Parent: Quinazolinamines
• Alternative Parents: Anisoles Aniline and substituted anilines Bromobenzenes Aminopyrimidines and derivatives Alkyl aryl ethers Imidolactams Aryl bromides Heteroaromatic compounds Secondary amines Azacyclic compounds Organopnictogen compounds Organobromides Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Quinazolinamine - Anisole - Aniline or substituted anilines - Alkyl aryl ether - Aminopyrimidine - Bromobenzene - Halobenzene - Aryl bromide - Aryl halide - Monocyclic benzene moiety - Pyrimidine - Benzenoid - Imidolactam - Heteroaromatic compound - Ether - Azacycle - Secondary amine - Organooxygen compound - Organonitrogen compound - Organobromide - Organohalogen compound - Hydrocarbon derivative - Organic oxygen compound - Amine - Organopnictogen compound - Organic nitrogen compound - Hydrochloride - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as quinazolinamines. These are heterocyclic aromatic compounds containing a quianazoline moiety substituted by one or more amine groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

EGFR Tclin Epidermal growth factor receptor (2 Activities)

Discover Target: EGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

Discover Target: EGFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB4 Tclin Receptor protein-tyrosine kinase erbB-4 (2748 Activities)

Discover Target: ERBB4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Alvos associados (não humanos)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: Solvent:DMSO, Max Conc. mg/mL: 3.97, Max Conc. mM: 10 with gentle warming
• Sensibilidade: Heat Sensitive
• Ponto de fusão (°C): 265 °C
• Peso molecular: 396.700 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 395.004 Da
• Monoisotopic Mass: 395.004 Da
• Topological Polar Surface Area: 56.300 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 360.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3