Perzinfotel - ≥98% , Glutamate [NMDA] receptor antagonist, CAS No.144912-63-0, Glutamate [NMDA] receptor antagonist

CAS: 144912-63-0 Cat. No.: P648963 Fórmula: C₉H₁₃N₂O₅P Peso molecular: 260.18 Número CE: 694-536-8 PubChem CID: 6918236

GRADE & PURITY ≥98%

Synonyms

D05447 | LKPOTIIKKKNIQY-UHFFFAOYSA-N | EAA-090 | 2-(dioxo-2,6-diazabicyclo(5.2.0)non-ethyl) phosphonic acid | HY-19168 | DTXSID70162846 | Perzinfotel (USAN/INN) | SCHEMBL371400 | NCGC00487176-01 | DHP, Dicetyl phosphate | BDBM86494 | EAA-090, >=98% (HPLC)

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Perzinfotel (EAA-090) is a potent, selective, and competitive NMDA receptor antagonist with neuroprotective effects. Perzinfotel (EAA-090) shows high affinity ( IC 50 =30 nM) for the glutamate site

In Vitro

Perzinfotel blocks NMDA-induced currents with an IC 50 of 0.48 μM and glutamate-induced neurotoxicity with an IC 50 of 1.6 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:NMDA receptor

Specifications

Sinónimos

D05447 | LKPOTIIKKKNIQY-UHFFFAOYSA-N | EAA-090 | 2-(dioxo-2,6-diazabicyclo(5.2.0)non-ethyl) phosphonic acid | HY-19168 | DTXSID70162846 | Perzinfotel (USAN/INN) | SCHEMBL371400 | NCGC00487176-01 | DHP, Dicetyl phosphate | BDBM86494 | EAA-090, >=98% (HPLC)

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

Perzinfotel (EAA-090) is a potent, selective, and competitive NMDA receptor antagonist with neuroprotective effects. Perzinfotel (EAA-090) shows high affinity ( IC 50 =30 nM) for the glutamate site.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

ANTAGONIST

Mecanismo de ação

Glutamate [NMDA] receptor antagonist

Pureza

≥98%

Propriedades do produto

• ALogP: -1.6

Nomes e identificadores

• Sorrisos canónicos: C1CNC2=C(C(=O)C2=O)N(C1)CCP(=O)(O)O
• IUPAC Name: 2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethylphosphonic acid
• InChIKey: BDABGOLMYNHHTR-UHFFFAOYSA-N
• INCHI: 1S/C9H13N2O5P/c12-8-6-7(9(8)13)11(3-1-2-10-6)4-5-17(14,15)16/h10H,1-5H2,(H2,14,15,16)
• SMILES isoméricas: C1CNC2=C(C(=O)C2=O)N(C1)CCP(=O)(O)O
• WGK Alemanha: 3
• PubChem CID: 6918236
• Peso molecular: 260.18

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Classe Organonitrogen compounds
      • Subclass Amines
        • Level5 Tertiary amines
          • Level6 Tertiary alkylarylamines
            • Level7 Dialkylarylamines

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Classe: Organonitrogen compounds
• Subclass: Amines
• Intermediate Tree Nodes: Tertiary amines - Tertiary alkylarylamines
• Direct Parent: Dialkylarylamines
• Alternative Parents: Secondary alkylarylamines 1,4-diazepines Vinylogous amides Organic phosphonic acids Azacyclic compounds Organopnictogen compounds Organophosphorus compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Dialkylarylamine - Para-diazepine - Secondary aliphatic/aromatic amine - Organophosphonic acid - Organophosphonic acid derivative - Vinylogous amide - Azacycle - Organoheterocyclic compound - Secondary amine - Organic oxygen compound - Hydrocarbon derivative - Organophosphorus compound - Organooxygen compound - Organic oxide - Organopnictogen compound - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as dialkylarylamines. These are aliphatic aromatic amines in which the amino group is linked to two aliphatic chains and one aromatic group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

GRIN1 Tclin Glutamate [NMDA] receptor (933 Activities)

Discover Target: GRIN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Alvos associados (não humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Glra1 Glycine receptor subunit alpha-1 (65 Activities)

Discover Target: Glra1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Brain (1 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Blood (6 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasma (328 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Grin1 Glutamate NMDA receptor (6467 Activities)

Discover Target: Grin1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: DMSO : 20.83 mg/mL (80.06 mM; Need ultrasonic) H2O : 5.88 mg/mL (22.60 mM; ultrasonic and warming and heat to 60°C)
• Peso molecular: 260.180 g/mol
• XLogP3: -1.600
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 260.056 Da
• Monoisotopic Mass: 260.056 Da
• Topological Polar Surface Area: 107.000 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 452.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1