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· · COA & SDS Disponível para todos os produtos · Envio no mesmo dia em itens em estoque PF 05175157 - ≥98%(HPLC) , Acetyl-CoA carboxylase inhibitor, CAS No.1301214-47-0, Acetyl-CoA carboxylase inhibitor
Disponível para encomenda
Synonyms
Z2327390391 | NCGC00421916-02 | s6672 | BCC21447 | (3-Methyl-5-isopropylphenyl)-N-methylcarbamat [German] | 1'-(2-methyl-3H-benzimidazole-5-carbonyl)-1-propan-2-ylspiro[4,6-dihydroindazole-5,4'-piperidine]-7-one | 1-Isopropyl-1'-(2-methyl-1H-benzo[d]imida
Shipped In
Ice chest + Ice pads
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Why this grade ≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Visão geral Product Application:
PF-05175157 is broad spectrum acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively.
Product Describtion:
PF-05175157 has been used as an acetyl-Coenzyme A carboxylase (ACC) inhibitor to study its effects on the infection of flavivirus.
Specifications Sinónimos
Z2327390391 | NCGC00421916-02 | s6672 | BCC21447 | (3-Methyl-5-isopropylphenyl)-N-methylcarbamat [German] | 1'-(2-methyl-3H-benzimidazole-5-carbonyl)-1-propan-2-ylspiro[4,6-dihydroindazole-5,4'-piperidine]-7-one | 1-Isopropyl-1'-(2-methyl-1H-benzo[d]imida
Especificações e pureza
≥98%(HPLC)
Mecanismos bioquímicos e fisiológicos
Acetyl-CoA carboxylase (ACC) 2 and 1 inhibitor (IC50values are 45 and 98 nM, respectively). Reduces hepatic and skeletal muscle malonyl-CoA levels in rats. Also inhibits hepaticde novolipogenesis and reduces whole body respiratory exchange ratio in rats.
Condições de armazenamento de armazenamento
Store at -20°C
Enviado em
Ice chest + Ice pads
Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.
Mecanismo de ação
Acetyl-CoA carboxylase inhibitor
Propriedades do produto Nomes e identificadores Pubchem Sid Url
https://pubchem.ncbi.nlm.nih.gov/substance/488201524
Sorrisos canónicos
CC1=NC2=C(N1)C=C(C=C2)C(=O)N3CCC4(CC3)CC5=C(C(=O)C4)N(N=C5)C(C)C
IUPAC Name
1'-(2-methyl-3H-benzimidazole-5-carbonyl)-1-propan-2-ylspiro[4,6-dihydroindazole-5,4'-piperidine]-7-one
InChIKey
BDXXSFOJPYSYOC-UHFFFAOYSA-N
INCHI
1S/C23H27N5O2/c1-14(2)28-21-17(13-24-28)11-23(12-20(21)29)6-8-27(9-7-23)22(30)16-4-5-18-19(10-16)26-15(3)25-18/h4-5,10,13-14H,6-9,11-12H2,1-3H3,(H,25,26)
SMILES isoméricas
CC1=NC2=C(N1)C=C(C=C2)C(=O)N3CCC4(CC3)CC5=C(C(=O)C4)N(N=C5)C(C)C
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Classe Piperidines Subclass N-acylpiperidines Intermediate Tree Nodes Not available Direct Parent N-benzoylpiperidines Alternative Parents Benzimidazoles Aryl alkyl ketones Benzenoids Tertiary carboxylic acid amides Pyrazoles Imidazoles Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents N-benzoylpiperidine - Benzimidazole - Aryl ketone - Aryl alkyl ketone - Benzenoid - Azole - Imidazole - Pyrazole - Tertiary carboxylic acid amide - Heteroaromatic compound - Carboxamide group - Ketone - Azacycle - Carboxylic acid derivative - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Aromatic heteropolycyclic compound Descrição This compound belongs to the class of organic compounds known as n-benzoylpiperidines. These are heterocyclic Compounds containing a piperidine ring conjugated to a benzyl group through one nitrogen ring atom. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Estrutura 3D Alvos associados (humanos) Alvos associados (não humanos) Mecanismos de ação Certificados（CoA,COO,BSE/TSE e Mapa de Análise) Propriedades químicas e físicas Solubilidade Solvent:DMSO, Max Conc. mg/mL: 20.27, Max Conc. mM: 50; Solvent:ethanol, Max Conc. mg/mL: 8.11, Max Conc. mM: 20 Sensibilidade light sensitive Peso molecular 405.500 g/mol XLogP3 2.700 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 4 Rotatable Bond Count 2 Exact Mass 405.216 Da Monoisotopic Mass 405.216 Da Topological Polar Surface Area 83.900 Ų Heavy Atom Count 30 Formal Charge 0 Complexity 689.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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