Phloretin (RJC 02792) - Moligand™, 10mM in DMSO , Inhibitor of AQP9;Channel blocker of ClC-3;Agonist of TAS2R14;Agonist of TAS2R39;Inhibitor of major facilitator superfamily domain containing 4B;Inhibitor of Sodium-dependent vitamin C transporter 1, CAS N, Inhibitor of AQP9;Channel blocker of ClC-3;Agonist of TAS2R14;Agonist of TAS2R39;Inhibitor of major facilitator superfamily domain containing 4B;Inhibitor of Sodium-dependent vitamin C transporter 1

CAS: 60-82-2 Cat. No.: P408181 Fórmula: C₁₅H₁₄O₅ Peso molecular: 274.27 Beilstein Registry Number: 1887240 Número CE: 200-488-7

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

NSC 407292, Dihydronaringenin | 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.
In vitro

Phloretin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2, though the inhibition is weaker than by its glycoside phlorizin. Orally consumed phlorizin is nearly entirely converted into phloretin by hydrolytic enzymes in the small intestine. An important effect of this is the inhibition of glucose absorption by the small intestine and the inhibition of renal glucose reabsorption. Phloretin also inhibits a variety of urea transporters. It induces urea loss and diuresis when coupled with high protein diets.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Sinónimos

NSC 407292, Dihydronaringenin | 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

AGONIST, CHANNEL BLOCKER, INHIBITOR

Mecanismo de ação

Inhibitor of AQP9;Channel blocker of ClC-3;Agonist of TAS2R14;Agonist of TAS2R39;Inhibitor of major facilitator superfamily domain containing 4B;Inhibitor of Sodium-dependent vitamin C transporter 1

Nomes e identificadores

SMILES isoméricas

C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O

WGK Alemanha

3

Peso molecular

274.27

Beilstein

1887240

Reaxy-Rn

1887240

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1887240&ln=

Alvos associados (humanos)

SLC23A1 Tchem Solute carrier family 23 member 1 (1 Activities)

Discover Target: SLC23A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLCN3 Tchem H(+)/Cl(-) exchange transporter 3 (1 Activities)

Discover Target: CLCN3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro
• Ponto de fusão (°C): 262°C

Perguntas frequentes

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 60-82-2, the molecular formula is C15H14O5, and the molecular weight is 274.27 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.