PHT-427 - Moligand™, 10mM in DMSO , Inhibitor of 3-phosphoinositide dependent protein kinase 1;Inhibitor of AKT serine/threonine kinase 2, CAS No.1191951-57-1, Inhibitor of 3-phosphoinositide dependent protein kinase 1;Inhibitor of AKT serine/threonine kinase 2

CAS: 1191951-57-1 Cat. No.: P409008 Fórmula: C₂₀H₃₁N₃O₂S₂ Peso molecular: 409.61

GRAU & PUREZA Moligand™, 10mM in DMSO

Synonyms

4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

PHT-427 PHT-427 (CS-0223) is a dual Akt and PDPK1 inhibitor (high affinity binding for the PH domains of Akt and PDPK1) with K i of 2.7 μM and 5.2 μM, respectively.
In vitro

PH-427 is a pleckstrin homology domain inhibitor to Akt/PDPK1. PH-427 significantly reduces phospho-Ser241-PDPK1 phospho-Thr308-Akt in PC-3 prostate cancer cells at 10 μM, which shows that PHT-427 could inhibit both Akt and PDPK1. PHT-427 also inhibits translocation of the Akt and PDPK1 PH domains in plasma membrane. PHT-427 induces apoptosis and inhibits AKT phosphorylation with IC50 of 8.6 μM (in BxPC-3 cells), which mainly on its Ser473 residue and less strongly on Thr308 residue without affecting total Akt protein expression. PHT-427 also shows antiproliferation in Panc-1 cells with IC50 of 65 μM.

In vivo

PHT-427 shows great antitumor activity in BxPC-3 pancreatic, MCF-7 breast and A-549 NSCL cancer xenografts. PHT-427 gives up to an 80% inhibition of tumor growth in BxPC-3 at doses of 125 to 250 mg/kg.
Cell Data

cell lines：

Concentrations：1-50 μM

Incubation Time：Incubation Time:

Powder Purity:≥99%

Especificações

Sinónimos

4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

PHT-427 (CS-0223) is a dual Akt and PDPK1 inhibitor (high affinity binding for the PH domains of Akt and PDPK1) with K_i of 2.7 μM and 5.2 μM, respectively.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

INHIBITOR

Mecanismo de ação

Inhibitor of 3-phosphoinositide dependent protein kinase 1;Inhibitor of AKT serine/threonine kinase 2

Nomes e identificadores

SMILES isoméricas

CCCCCCCCCCCCC1=CC=C(C=C1)S(=O)(=O)NC2=NN=CS2

Peso molecular

409.61

Reaxy-Rn

19687633

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19687633&ln=

Alvos associados (humanos)

AKT2 Tchem RAC-beta serine/threonine-protein kinase (1 Activities)

Discover Target: AKT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDPK1 Tchem 3-phosphoinositide-dependent protein kinase 1 (1 Activities)

Discover Target: PDPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Perguntas frequentes

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1191951-57-1, the molecular formula is C20H31N3O2S2, and the molecular weight is 409.61 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.