≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Armazenar a -20°C Ships Arca de gelo + almofadas de gelo Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Visão geral
Um composto de imidazoquinazolina permeável às células que actua como um inibidor potente, reversível e competitivo de ATP contra todas as três classes de PI 3-K quinases (IC50 = 11, 18, 47, 58, 64, 350 e 830 nM contra p110α, p110γ, PI 3-KC2α, p110δ, PI 3-KC2β, p110β e hsVPS34, respetivamente), bem como vários PIKKs (IC50 = 13, 610 e 1050 nM contra DNA-PK, ATM e mTORC1, respetivamente) e PI 4-KIIIα (IC50 = 830 nM), enquanto exibem potência muito reduzida contra PI 4-KIIIβ e ATR (IC50 = 3.1 e 15 µM, respetivamente) e pouca ou nenhuma atividade contra PI 4-KIIα, PIPKs (IC50 >100 µM), e um painel de 36 proteínas cinases comummente estudadas (<15% inhibition at 10 µM). Effectively suppreses insulin-stimulated phosphorylations of Akt and rpS6 in 3T3-L1 adipocytes and L6 myotubes in a dose-dependent manner in vitro (by >90% a 2,5 µM) e previne completamente o declínio da glucose no sangue induzido pela insulina em ratos in vivo (10 mg/ml, i.p.).
This compound belongs to the class of organic compounds known as quinazolinamines. These are heterocyclic aromatic compounds containing a quianazoline moiety substituted by one or more amine groups.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
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