≥95%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Product Application:
Protein degrader builiding block Pomalidomide-PEG3-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
| Pubchem Sid | 488202763 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488202763 |
| Sorrisos canónicos | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCOCCC(=O)O |
| IUPAC Name | 3-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]propanoic acid |
| InChIKey | QBYOEHKZQIFBGV-UHFFFAOYSA-N |
| INCHI | 1S/C22H27N3O9/c26-17-5-4-16(20(29)24-17)25-21(30)14-2-1-3-15(19(14)22(25)31)23-7-9-33-11-13-34-12-10-32-8-6-18(27)28/h1-3,16,23H,4-13H2,(H,27,28)(H,24,26,29) |
| PubChem CID | 132020335 |
| Peso molecular | 477.46 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Data | Item |
|---|---|---|---|
 C2620070 | Certificate of Analysis | Apr 06, 2026 | P288042 |
| C2315860 | Certificate of Analysis | Jan 12, 2026 | P288042 |
| C2315861 | Certificate of Analysis | Jan 12, 2026 | P288042 |
| C2315862 | Certificate of Analysis | Jan 12, 2026 | P288042 |
| C2315863 | Certificate of Analysis | Jan 12, 2026 | P288042 |
| C2315864 | Certificate of Analysis | Jan 12, 2026 | P288042 |
| C2315865 | Certificate of Analysis | Jan 12, 2026 | P288042 |
| C2315866 | Certificate of Analysis | Jan 12, 2026 | P288042 |
| C2315867 | Certificate of Analysis | Jan 12, 2026 | P288042 |
| Peso molecular | 477.500 g/mol |
|---|---|
| XLogP3 | -0.100 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 14 |
| Exact Mass | 477.175 Da |
| Monoisotopic Mass | 477.175 Da |
| Topological Polar Surface Area | 161.000 Ų |
| Heavy Atom Count | 34 |
| Formal Charge | 0 |
| Complexity | 775.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
