Pomalidomide-PEG₆-CO₂H - ≥98% , CAS No.2225148-49-0

CAS: 2225148-49-0 Cat. No.: P486908 Fórmula: C₂₈H₃₉N₃O₁₂ Peso molecular: 609.62 PubChem CID: 139034004

GRADE & PURITY ≥98%

Synonyms

1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid | Crosslinker−E3 Ligase ligand conjugate | Pomalidomide-PEG6-COOH

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Visão geral

Description

Protein degrader builiding block Pomalidomide-PEG6-CO2H enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Specifications

Sinónimos

1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid | Crosslinker−E3 Ligase ligand conjugate | Pomalidomide-PEG6-COOH

Especificações e pureza

≥98%

Condições de armazenamento de armazenamento

Store at -20°C,Argon charged

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥98%

Nomes e identificadores

• Pubchem Sid: 504773551
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773551
• Sorrisos canónicos: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCOCCOCCOCCOCCC(=O)O
• IUPAC Name: 3-[2-[2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChIKey: NBDBXIANAMQQQU-UHFFFAOYSA-N
• INCHI: 1S/C28H39N3O12/c32-23-5-4-22(26(35)30-23)31-27(36)20-2-1-3-21(25(20)28(31)37)29-7-9-39-11-13-41-15-17-43-19-18-42-16-14-40-12-10-38-8-6-24(33)34/h1-3,22,29H,4-19H2,(H,33,34)(H,30,32,35)
• PubChem CID: 139034004
• Peso molecular: 609.62

Propriedades químicas e físicas

• Sensibilidade: Moisture sensitive
• Ponto de inflamação (°F): Not applicable
• Ponto de inflamação (°C): Not applicable