Pramipexole 2HCl Mono-hidratado - ≥98%(HPLC) , D2-like dopamine receptor agonist, CAS No.191217-81-9, D2-like dopamine receptor agonist

CAS: 191217-81-9 Cat. No.: P129443 Fórmula: C₁₀H₁₇N₃S·2HCl·H₂O Peso molecular: 302.26 Número CE: 687-708-9 PubChem CID: 166589

GRADE & PURITY ≥98%(HPLC)

Synonyms

PRAMIPEXOLE DIHYDROCHLORIDE [USP MONOGRAPH] | SCHEMBL25118 | CCG-267486 | Mirapex (TN) | PRAMIPEXOLE HYDROCHLORIDE HYDRATE [JAN] | Pramipexole Hydrochloride Monohydrate | T72003 | UNII-3D867NP06J | D00559 | s2011 | HY-B0410A | APVQOOKHDZVJEX-QTPLPEIMSA-N

Storage

Armazenar a 2-8°C

Shipped In

Gelo húmido

Visão geral

O pramipexole 2HCl mono-hidratado é um agonista parcial/completo dos receptores D2S, D2L, D3, D4, com um Ki de 3,9, 2,2, 0,5, 5,1 nM.
Um agonista da dopamina não ergolínico.

Specifications

Sinónimos

PRAMIPEXOLE DIHYDROCHLORIDE [USP MONOGRAPH] | SCHEMBL25118 | CCG-267486 | Mirapex (TN) | PRAMIPEXOLE HYDROCHLORIDE HYDRATE [JAN] | Pramipexole Hydrochloride Monohydrate | T72003 | UNII-3D867NP06J | D00559 | s2011 | HY-B0410A | APVQOOKHDZVJEX-QTPLPEIMSA-N

Especificações e pureza

≥98%(HPLC)

Mecanismos bioquímicos e fisiológicos

O pramipexol é um agonista da dopamina ativo nos subtipos de receptores D3 e D2. Verificou-se que o pramipexole tem efeitos neuroprotectores independentes do seu agonismo dos receptores da dopamina. Reduz a produção de espécies reactivas de oxigénio mitoc

Condições de armazenamento de armazenamento

Armazenar a 2-8°C

Enviado em

Gelo húmido

Tipo de ação

AGONIST

Mecanismo de ação

D2-like dopamine receptor agonist

Nota

Tóxico, consultar a FDS para mais informações. Precisa de mais conselhos sobre solubilidade, utilização e manuseamento? Para mais informações, visite a nossa página de perguntas frequentes (FAQ).

Pureza

≥98%(HPLC)

Nomes e identificadores

Pubchem Sid

504757593

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504757593

Sorrisos canónicos

CCCNC1CCC2=C(C1)SC(=N2)N.O.Cl.Cl

IUPAC Name

(6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine;hydrate;dihydrochloride

InChIKey

APVQOOKHDZVJEX-QTPLPEIMSA-N

INCHI

1S/C10H17N3S.2ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H;1H2/t7-;;;/m0.../s1

SMILES isoméricas

CCCN[C@H]1CCC2=C(C1)SC(=N2)N.O.Cl.Cl

CAS alternativo

191217-81-9

PubChem CID

166589

Termos de entrada MeSH

2 Amino 6 propylaminotetrahydrobenzothiazole;2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole;2-amino-6-propylaminotetrahydrobenzothiazole;4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine;6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine dihydr

Peso molecular

302.26

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Classe Organonitrogen compounds
      • Subclass Amines

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Classe: Organonitrogen compounds
• Subclass: Amines
• Intermediate Tree Nodes: Not available
• Direct Parent: Aralkylamines
• Alternative Parents: 2-amino-1,3-thiazoles Heteroaromatic compounds Dialkylamines Azacyclic compounds Primary amines Organopnictogen compounds Organic oxides Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Aralkylamine - 1,3-thiazol-2-amine - Azole - Thiazole - Heteroaromatic compound - Secondary aliphatic amine - Secondary amine - Azacycle - Organoheterocyclic compound - Organic oxygen compound - Hydrochloride - Hydrocarbon derivative - Organic oxide - Primary amine - Organopnictogen compound - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as aralkylamines. These are alkylamines in which the alkyl group is substituted at one carbon atom by an aromatic hydrocarbyl group.
• External Descriptors: hydrate

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (não humanos)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: Soluble in water (61 mg/ml at 25 °C), DMSO (41 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
• Rotação específica [α]: -67° (C=1,MeOH)
• Ponto de fusão (°C): 296-305°C
• Peso molecular: 302.300 g/mol
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 301.078 Da
• Monoisotopic Mass: 301.078 Da
• Topological Polar Surface Area: 80.200 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 188.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 4

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