Probucol - Moligand™, 10mM in DMSO , ATP-binding cassette sub-family A member 1 inhibitor, CAS No.23288-49-5, ATP-binding cassette sub-family A member 1 inhibitor

CAS: 23288-49-5 Cat. No.: P408795 Fórmula: C₃₁H₄₈O₂S₂ Peso molecular: 516.84 Número CE: 245-560-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

DH-581 | 4,​4'-​[(1-​methylethylidene)​bis(thio)​]​bis[2,​6-​bis(1,​1-​dimethylethyl)​-phenol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Probucol Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

DH-581 | 4,​4'-​[(1-​methylethylidene)​bis(thio)​]​bis[2,​6-​bis(1,​1-​dimethylethyl)​-phenol

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

INHIBITOR

Mecanismo de ação

ATP-binding cassette sub-family A member 1 inhibitor

Propriedades do produto

• ALogP: 11.3

Nomes e identificadores

• SMILES isoméricas: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SC(C)(C)SC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C
• RTECS: AL3705000
• Peso molecular: 516.84
• Reaxy-Rn: 2026253
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2026253&ln=

Alvos associados (humanos)

HPN Tchem Serine protease hepsin (1 Activities)

Discover Target: HPN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro
• Ponto de fusão (°C): 128°C

Referências

1. Xiaowei Wang, Wenjun Zhang, Sheng Zeng, Liudi Wang, Bin Wang.  (2023)  Collagenase Type I and Probucol-Loaded Nanoparticles Penetrate the Extracellular Matrix to Target Hepatic Stellate Cells for Hepatic Fibrosis Therapy.  Acta Biomaterialia,      [PMID:38141933] [10.1016/j.actbio.2023.12.027]

2. Hongyan Lu, Guangzhao Yang, Fu Ran, Tianbin Gao, Changshan Sun, Qinfu Zhao, Siling Wang.  (2019)  Polymer-functionalized mesoporous carbon nanoparticles on overcoming multiple barriers and improving oral bioavailability of Probucol.  CARBOHYDRATE POLYMERS,      [PMID:31826471] [10.1016/j.carbpol.2019.115508]