Propidium iodide（PI） - 10mM in DMSO , CAS No.25535-16-4

CAS: 25535-16-4 Cat. No.: P422887 Fórmula: C₂₇H₃₄I₂N₄ Peso molecular: 668.39 Beilstein Registry Number: 3843838 Número CE: 247-081-0 PubChem CID: 104981

GRADE & PURITY 10mM in DMSO

Synonyms

2,7-Diamino-9-phenyl-10 (diethylaminopropyl)-phenanthridium iodide methiodide | HMS3403D19 | Propidium Iodine | 3,8-Diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diiodide | 3,8-Diamino-5-(3-(diethylmethylammonio)propyl)-6-phenylphena

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Propidium iodide is a fluorescent intercalating agent used for staining.It functions as an apoptosis marker and has linear DNA-binding capacity. Propidium iodide is an effective indicator of tissue injury

Fluorescent stain for nucleic acids. Cell membrane integrity excludes propidium iodide from staining viable and apoptotic cells. Propidium iodide may be used in flow cytometry to evaluate cell viability when used with other dyes that stain viable cells or cells that are early in the apoptosis process.

Specifications

Sinónimos

2,7-Diamino-9-phenyl-10 (diethylaminopropyl)-phenanthridium iodide methiodide | HMS3403D19 | Propidium Iodine | 3,8-Diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diiodide | 3,8-Diamino-5-(3-(diethylmethylammonio)propyl)-6-phenylphena

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Red-fluorescent DNA stain. Membrane impermeant to live cells. Propidium iodide staining differentiates between live and dead cells in cell populations.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Nomes e identificadores

• Pubchem Sid: 528774189
• Sorrisos canónicos: CC[N+](C)(CC)CCC[N+]1=C2C=C(C=CC2=C3C=CC(=CC3=C1C4=CC=CC=C4)N)N.[I-].[I-]
• IUPAC Name: 3-(3,8-diamino-6-phenylphenanthridin-5-ium-5-yl)propyl-diethyl-methylazanium;diiodide
• InChIKey: XJMOSONTPMZWPB-UHFFFAOYSA-M
• INCHI: 1S/C27H33N4.2HI/c1-4-31(3,5-2)17-9-16-30-26-19-22(29)13-15-24(26)23-14-12-21(28)18-25(23)27(30)20-10-7-6-8-11-20;;/h6-8,10-15,18-19,29H,4-5,9,16-17,28H2,1-3H3;2*1H/q+1;;/p-1
• SMILES isoméricas: CC[N+](C)(CC)CCC[N+]1=C2C=C(C=CC2=C3C=CC(=CC3=C1C4=CC=CC=C4)N)N.[I-].[I-]
• WGK Alemanha: 3
• RTECS: SF7949600
• PubChem CID: 104981
• Peso molecular: 668.39
• Beilstein: 3843838

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Quinolines and derivatives
      • Subclass Phenylquinolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Quinolines and derivatives
• Subclass: Phenylquinolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylquinolines
• Alternative Parents: Phenanthridines and derivatives Phenylpyridines Isoquinolines and derivatives Benzene and substituted derivatives Tetraalkylammonium salts Heteroaromatic compounds Azacyclic compounds Primary amines Organopnictogen compounds Organic iodide salts Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenylquinoline - Benzoquinoline - Phenanthridine - 2-phenylpyridine - Isoquinoline - Monocyclic benzene moiety - Benzenoid - Pyridine - Tetraalkylammonium salt - Heteroaromatic compound - Quaternary ammonium salt - Azacycle - Organic salt - Organic iodide salt - Amine - Organonitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Organic nitrogen compound - Primary amine - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as phenylquinolines. These are heterocyclic compounds containing a quinoline moiety substituted with a phenyl group.
• External Descriptors: organic iodide salt

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

ACHE Tclin Acetylcholinesterase (18204 Activities)

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BCHE Tclin Butyrylcholinesterase (7174 Activities)

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APP Tclin Amyloid-beta A4 protein (8510 Activities)

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BACE1 Tchem Beta-secretase 1 (15641 Activities)

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

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BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)

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BCHE Tclin Cholinesterases; ACHE & BCHE (1222 Activities)

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Alvos associados (não humanos)

pol Human immunodeficiency virus type 1 reverse transcriptase (18245 Activities)

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Plasmodium falciparum (966862 Activities)

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Calf thymus DNA (4845 Activities)

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GCN5 Histone acetyltransferase GCN5 (89 Activities)

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Luciferin 4-monooxygenase (66902 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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BCHE Cholinesterase (8742 Activities)

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TGR Thioredoxin glutathione reductase (28579 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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Grin1 Glutamate NMDA receptor (6467 Activities)

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Mecanismos de ação

Propriedades químicas e físicas

• Sensibilidade: Hygroscopic,Light sensitive
• Ponto de fusão (°C): 220-225°C
• Peso molecular: 668.400 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 668.087 Da
• Monoisotopic Mass: 668.087 Da
• Topological Polar Surface Area: 55.900 Ų
• Heavy Atom Count: 33
• Formal Charge: 0
• Complexity: 555.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3