PROTAC BRD4 Degrader-8 - ≥98% , CAS No.P659242

CAS: P659242 Cat. No.: P659242 Fórmula: C₅₃H₆₁F₂N₉O₁₁S₂ Peso molecular: 1102.23

GRAU & PUREZA ≥98%

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

PROTAC BRD4 Degrader-8 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 , with IC 50 s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2 , respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer

Appearance:Solid

IC50& Target:IC50: 1.1 nM (BRD4 BD1), 1.4 nM (BRD4 BD2)

In Vitro:PROTAC BRD4 Degrader-8 (compound 8; 6 days) inhibits the proliferation of PC3 prostate cancer cells, with an IC 50 of 28 nM. PROTAC BRD4 Degrader-8 (4 h) suppresses MYC gene transcript in MV4-11 AML cells, with an IC 50 of 11 nM. PROTAC BRD4 Deg

Biological Activity:PROTAC BRD4 Degrader-8 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 , with IC 50 s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2 , respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer

Especificações

Especificações e pureza

≥98%

Condições de armazenamento de armazenamento

Protected from light,Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Pureza

≥98%

Nomes e identificadores

Peso molecular

1102.23

Propriedades químicas e físicas

• Solubilidade: DMSO : 90 mg/mL (81.65 mM; Need ultrasonic)

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is P659242, the molecular formula is C53H61F2N9O11S2, and the molecular weight is 1102.23 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.