PSB 1115 - ≥98% , CAS No.409344-71-4 anhydrous

CAS: 409344-71-4 anhydrous Cat. No.: P335272 Fórmula: C₁₄H₁₃N₄O₅SK Peso molecular: 388.44 PubChem CID: 5311479

GRADE & PURITY ≥98%

Synonyms

CHEBI:92848 | GTPL3286 | composto 17 [PMID: 11906291] | EX-A7843 | AKOS02424456909 | SCHEMBL1223271 | SR-01000597529-1 | Q27088472 | PSB 1115 | HMS3677C03 | PSB1115 | PSB-1115 | BRD-K49027941-237-01-1 | NCGC00025344-01 | DTXSID80415532 | Tocris-2009 | BDB

Storage

Armazenar a 2-8°C,Dessecado

Shipped In

Gelo húmido

Visão geral

O PSB 1115 é um antagonista da adenosina A2B-R humana, altamente seletivo e solúvel em água. Os valores de K|i| são 53,4 > 10000 e > 10000 nM na Adenosina A2B-R humana, Adenosina A1-R e Adenosina A3-R, respetivamente. Este composto é também seletivo em relação à Adenosina A1-R e à Adenosina A2A-R de rato (os valores de K|i| são 2200 e 24000 nM, respetivamente). O PSB 1115 é um inibidor da Adenosina A1-R.

Specifications

Sinónimos

CHEBI:92848 | GTPL3286 | composto 17 [PMID: 11906291] | EX-A7843 | AKOS02424456909 | SCHEMBL1223271 | SR-01000597529-1 | Q27088472 | PSB 1115 | HMS3677C03 | PSB1115 | PSB-1115 | BRD-K49027941-237-01-1 | NCGC00025344-01 | DTXSID80415532 | Tocris-2009 | BDB

Especificações e pureza

≥98%

Condições de armazenamento de armazenamento

Armazenar a 2-8°C,Dessecado

Enviado em

Gelo húmido

Pureza

≥98%

Propriedades do produto

Dados Ki

Adenosine A2B-R: Ki= 53.4 nM (human); A1 receptor: Ki= 2.2 μM (rat); Adenosine A1-R: Ki= >10 μM (human); Adenosine A3-R: Ki= >10 μM (human); A2A receptor: Ki= 24 μM (rat)

Nomes e identificadores

SMILES isoméricas

CCCN1C(=O)C2=C(NC1=O)N=C(N2)C3=CC=C(C=C3)S(=O)(=O)O

WGK Alemanha

3

PubChem CID

5311479

Peso molecular

388.44

Alvos associados (humanos)

ADORA2A Tclin Adenosine receptor A2a (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA2B Tclin Adenosine receptor A2b (5 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA1 Tclin Adenosine receptor A1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA3 Tchem Adenosine receptor A3 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADORA1 Tclin Adenosine A1 receptor (17603 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADORA2A Tclin Adenosine A2a receptor (16305 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADORA2B Tclin Adenosine A2b receptor (7672 Activities)

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ADORA3 Tchem Adenosine A3 receptor (15931 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLA Tclin Alpha-galactosidase A (5444 Activities)

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GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)

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ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

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CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

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HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

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KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)

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MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

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Alvos associados (não humanos)

Cruzipain (33337 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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GCN5 Histone acetyltransferase GCN5 (89 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Impa1 Inositol monophosphatase 1 (16203 Activities)

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FTL Ferritin light chain (43324 Activities)

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Adora2b Adenosine A2 receptor (1828 Activities)

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Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: Soluble in DMSO (20 mM), and water (5 mM).
• Índice de refração: n20D~1.64 (Predicted)
• Peso molecular: 350.350 g/mol
• XLogP3: 0.700
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 350.068 Da
• Monoisotopic Mass: 350.068 Da
• Topological Polar Surface Area: 141.000 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 611.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 409344-71-4 anhydrous, the molecular formula is C14H13N4O5SK, and the molecular weight is 388.44 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.