PX-478 2HCl - 10mM in DMSO , CAS No.685898-44-6

CAS: 685898-44-6 Cat. No.: P408756 Fórmula: C₁₃H₂₀Cl₄N₂O₃ Peso molecular: 394.12 PubChem CID: 11234794

GRADE & PURITY 10mM in DMSO

Synonyms

4-[bis(2-chloroethyl)oxidoamino]-L-phenylalanine,hydrochloride (1:2)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

PX-478 2HCl PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1.
In vitro

PX-478 lowers HIF-1α protein levels and HIF-1 transactivation in hypoxia and in normoxia in a variety of cancer cell lines, but has a more pronounced effect on translation of proteins, such as HIF-1α in hypoxia. PX-478 also enhances the radiosensitivity of prostate carcinoma PC3 cells.

In vivo

In HT-29 human colon cancer xenografts, PX-478 suppresses HIF-1alpha levels and inhibits the expression of HIF-1 target genes including vascular endothelial growth factor and the glucose transporter-1. In addition, PX-478 (100 or 120 mg/kg i.p.) also shows antitumor activity including cures against several established human tumor xenografts that is related to the levels of HIF-1α. In high-fat-diet mice, PX-478 causes reduced fibrosis and fewer inflammatory infiltrates in their adipose tissues.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:

Specifications

Sinónimos

4-[bis(2-chloroethyl)oxidoamino]-L-phenylalanine,hydrochloride (1:2)

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Propriedades do produto

ALogP

-0.251

Contagem HBD

1

Ligação rotativa

8

Nomes e identificadores

SMILES isoméricas

C1=CC(=CC=C1C[C@@H](C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl

PubChem CID

11234794

Peso molecular

394.12

Propriedades químicas e físicas

• DMSO (mg/mL) Solubilidade máxima: 78
• DMSO (mM) Solubilidade máxima: 197.9092662
• Água (mg/mL) Solubilidade máxima: 78
• Água (mM) Solubilidade máxima: 197.9092662

Perguntas frequentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 685898-44-6, the molecular formula is C13H20Cl4N2O3, and the molecular weight is 394.12 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.