QWF,TFA salt, CAS No.126088-82-2(free)

CAS: 126088-82-2(free) Cat. No.: Q288607 Fórmula: C₃₈H₄₃N₅O₈(free) Peso molecular: 697.78(free)

GRADE & PURITY Moligand™, ≥95%

Visão geral

Product description：

Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.
Application：

QWF is a tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo.

Specifications

Product Name

QWF,TFA salt, CAS No.126088-82-2(free)

Sinónimos

N(alpha)-(N(alpha)-(N(alpha)-(tert-butyloxycarbonyl)glutaminyl)-N(1)-formyl-tryptophyl)phenylalanine | Boc-gln-trp(cho)-phe-obzl | QWF | Boc-Gln-D-Trp(CHO)-Phe-OBzl | BDBM50002533 | L-Phenylalanine, N-(N-(N2-((1,1-dimethylethoxy)carbonyl)-L-glutaminyl)-1-

Grau

Moligand™

Especificações e pureza

Moligand™, ≥95%

Mecanismos bioquímicos e fisiológicos

Tripeptide substance P (SP) antagonist (IC50= 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cellsin vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in

Sequência

Boc-Gln-D-Trp(Formyl)-Phe-OBzl

Tipo de ação

ANTAGONIST

CAS

126088-82-2(free)

Tipo de molécula

Peptide

Armazenamento e envio

Condições de armazenamento de armazenamento

Store at -20°C,Argon charged

Enviado em

Ice chest + Ice pads

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Classe Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Oligopeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Classe: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Oligopeptides
• Alternative Parents: Phenylalanine and derivatives Glutamine and derivatives Alpha amino acid esters N-acyl-alpha amino acids and derivatives Tryptamines and derivatives Alpha amino acid amides Benzyloxycarbonyls Amphetamines and derivatives 3-alkylindoles Fatty acid esters N-acyl amines Substituted pyrroles Heteroaromatic compounds Carbamate esters Primary carboxylic acid amides Secondary carboxylic acid amides Carboxylic acid esters Organic carbonic acids and derivatives Monocarboxylic acids and derivatives Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides Organonitrogen compounds Organopnictogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Alpha-oligopeptide - Phenylalanine or derivatives - Glutamine or derivatives - Alpha-amino acid ester - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Triptan - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - 3-alkylindole - Benzyloxycarbonyl - Amphetamine or derivatives - Indole or derivatives - Indole - Fatty acid ester - Benzenoid - N-acyl-amine - Substituted pyrrole - Fatty acyl - Monocyclic benzene moiety - Fatty amide - Carbamic acid ester - Pyrrole - Heteroaromatic compound - Carboxamide group - Carboxylic acid ester - Secondary carboxylic acid amide - Primary carboxylic acid amide - Carbonic acid derivative - Organoheterocyclic compound - Azacycle - Monocarboxylic acid or derivatives - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Organic oxide - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

TACR1 Tclin Neurokinin 1 receptor (6273 Activities)

Discover Target: TACR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Alvos associados (não humanos)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação