Rbin-1 - ≥98% , CAS No.328023-11-6

CAS: 328023-11-6 Cat. No.: R413990 Fórmula: C₁₃H₁₂N₄S Peso molecular: 256.33 PubChem CID: 5731061

GRAU & PUREZA ≥98%

Synonyms

Rbin-1|Ribozinoindole-1|Butane,3-dibromo-, (R*,S*)-|Cambridge id 6586001|3-[(2-methyl-2-propenyl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole|NITROINDAZOLE, 5-|3-((2-methylallyl)thio)-5H-[1,2,4]triazino[5,6-b]indole|3-[(2-methylprop-2-en-1-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole|3-[(2-methylprop-2-en-1-yl)thio]-5H-[1,2,4]triazino[5,6-b]indole|3-(2-Methylallylthio)-5H-[1,2,4]triazino[5,6-b]indole|3-[(2-Methyl-2-propen-1-yl)thio]-5H-1,2,4-triazino[5,6-b]indole|3-(2-methylprop-2-enylsulfanyl)-5H-[1,2,4]triazino[5,6-b]indole

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Information

Rbin-1 Rbin-1 (Ribozinoindole-1) is a potent chemical inhibitor of eukaryotic ribosome assembly . It inhibits recombinant full-length Mdn1's ATPase activity in vitro.

Targets

Mdn1

In vitro

Ribozinoindoles are potent chemical inhibitors of eukaryotic ribosome assembly. Rbin-1 targets Mdn1 or cellular processes that involve this protein. It efficiently inhibit the growth of yeast cells.

Especificações

Sinónimos

Rbin-1 | Ribozinoindole-1 | Butane,3-dibromo-, (R*,S*)- | Cambridge id 6586001 | 3-[(2-methyl-2-propenyl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole | NITROINDAZOLE, 5- | 3-((2-methylallyl)thio)-5H-[1,2,4]triazino[5,6-b]indole | 3-[(2-methylprop-2-en-1-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole | 3-[(2-methylprop-2-en-1-yl)thio]-5H-[1,2,4 Show more

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

Rbin-1 (Ribozinoindole-1) is a potent chemical inhibitor of eukaryotic ribosome assembly. It inhibits recombinant full-length Mdn1's ATPase activity in vitro.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥98%

Propriedades do produto

ALogP

3.83

Contagem HBD

1

Ligação rotativa

3

Nomes e identificadores

Pubchem Sid

504763955

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504763955

Sorrisos canónicos

CC(=C)CSC1=NC2=C(C3=CC=CC=C3N2)N=N1

IUPAC Name

3-(2-methylprop-2-enylsulfanyl)-5H-[1,2,4]triazino[5,6-b]indole

InChIKey

LPCWHNSRTRBKBO-UHFFFAOYSA-N

INCHI

1S/C13H12N4S/c1-8(2)7-18-13-15-12-11(16-17-13)9-5-3-4-6-10(9)14-12/h3-6H,1,7H2,2H3,(H,14,15,17)

SMILES isoméricas

CC(=C)CSC1=NC2=C(C3=CC=CC=C3N2)N=N1

PubChem CID

5731061

Peso molecular

256.33

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Indoles and derivatives
      • Subclass Indoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Indoles and derivatives
• Subclass: Indoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Indoles
• Alternative Parents: Alkylarylthioethers Benzenoids 1,2,4-triazines Pyrroles Heteroaromatic compounds Sulfenyl compounds Azacyclic compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Indole - Aryl thioether - Alkylarylthioether - Triazine - Benzenoid - 1,2,4-triazine - Pyrrole - Heteroaromatic compound - Sulfenyl compound - Thioether - Azacycle - Hydrocarbon derivative - Organosulfur compound - Organonitrogen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as indoles. These are compounds containing an indole moiety, which consists of pyrrole ring fused to benzene to form 2,3-benzopyrrole.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 19.5 mg/mL warmed with 50ºC Water: bath (76.07 mM); Ethanol: 1 mg/mL (3.9 mM); Water: Insoluble
• DMSO (mg/mL) Solubilidade máxima: 23
• DMSO (mM) Solubilidade máxima: 89.72808489
• Água (mg/mL) Solubilidade máxima: ＜1
• Peso molecular: 256.329 g/mol
• XLogP3: 3.200
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 256.078 Da
• Monoisotopic Mass: 256.078 Da
• Topological Polar Surface Area: 79.800 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 322.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1