RFRP 3 (human) TFA, CAS No.311309-27-0(free)

CAS: 311309-27-0(free) Cat. No.: R409332 Fórmula: C₄₅H₇₂N₁₄O₁₀·C₂HF₃O₂ Peso molecular: 1083.15

GRADE & PURITY ≥98%

Visão geral

Product Description
RFRP-3 TFA efficiently inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM. Scatchard-plot analysis shows that 125I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the Kd value and the Bmax values are 0.19 nM and 1.3 pM, respectively. RFRP-3 TFA specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (Kd= 0.19 nM). RFRP-3 (10-8 to 10-14M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination.

Specifications

Product Name

RFRP 3 (human) TFA, CAS No.311309-27-0(free)

Sinónimos

Neuropeptide VF(124-131)(human) TFA | RFRP-3 human trifluoroacetate salt | Neuropeptide VF (124-131), NPVF, RFamide-related peptide-3

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

RFRP-3 (RFamide-related peptide-3) is a homolog of avian gonadotropin-inhibitory hormone. RFRP-3 binds to the GPR147 receptor (also known as neuropeptide FF receptor 1). RFRP-3 blocks release of gonadotropin from the pituitary, and inhibits FSH-, LH- and

Sequência

Val-Pro-Asn-Leu-Pro-Gln-Arg-Phe-NH2

CAS

311309-27-0(free)

Tipo de molécula

Peptide

Armazenamento e envio

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Perguntas frequentes

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 311309-27-0(free).

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.