Rosiptor - Moligand™, 10 mM in DMSO , CAS No.782487-28-9

CAS: 782487-28-9 Cat. No.: R1494221 Fórmula: C₂₀H₃₅NO₂ Peso molecular: 321.5 PubChem CID: 76965484

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro .

Specifications

Especificações e pureza

Moligand™, 10 mM in DMSO

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

ACTIVATOR

Propriedades do produto

• ALogP: 3

Nomes e identificadores

• SMILES isoméricas: C[C@@]1(CC[C@@H](C[C@@H]1CO)O)[C@H]2CC[C@]3([C@H]([C@@H]2CN)CCC3=C)C
• PubChem CID: 76965484
• Peso molecular: 321.5

Referências

1. Li Gao, Junsheng Zhang, Tingting Yang, Ling Jiang, Xueqi Liu, Sheng Wang, Xian Wang, Yuebo Huang, Huaying Wang, Mengya Zhang, Tingting Gong, Lijuan Ma, Chao Li, Chaoyong He, Xiao-ming Meng, Yonggui Wu.  (2023)  STING/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease.  MOLECULAR THERAPY,      [PMID:37533255] [10.1016/j.ymthe.2023.07.026]

2. Fangyuan Chen, Qingmei Liu, Lei Ma, Cuishi Yan, Haiman Zhang, Zhi Zhou, Wei Yi.  (2024)  Identification of Novel Organo-Se BTSA-Based Derivatives as Potent, Reversible, and Selective PPARγ Covalent Modulators for Antidiabetic Drug Discovery.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:39705161] [10.1021/acs.jmedchem.4c02803]

3. Zheng Xiao, Peng Luo, Guoli Li, Huifang Tan, Chen Zhou, Dong Zeng, Yinyin Chen, Ying Li.  (2025)  HPDA-based tubule-targeting nanoplatform alleviates oxidative stress and ferroptosis for the reversal of renal interstitial fibrosis.  JOURNAL OF NANOBIOTECHNOLOGY,      [PMID:41390419] [10.1186/s12951-025-03927-5]