RP 70676 - Moligand™,10mM in DMSO , CAS No.136609-26-2

CAS: 136609-26-2 Cat. No.: R655832 Fórmula: C₂₅H₂₈N₄S Peso molecular: 416.58 PubChem CID: 9844830

GRAU & PUREZA Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

RP 70676 is a potent inhibitor of ACAT , with IC 50 of 25 and 44 nM for rat and rabbit ACAT .

In Vitro

RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC 50 = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC 50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC 50 is 44 nM. In whole cell P388D, murine macrophages the compound has an IC 50 of 540 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 25 nM (Rat ACAT), 44 nM (Rabbit ACAT)

Especificações

Especificações e pureza

Moligand™,10mM in DMSO

Mecanismos bioquímicos e fisiológicos

RP 70676 is a potent inhibitor of ACAT , with IC 50 of 25 and 44 nM for rat and rabbit ACAT .

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

INHIBITOR

Nomes e identificadores

SMILES isoméricas

CC1=CC(=NN1CCCCCSC2=NC(=C(N2)C3=CC=CC=C3)C4=CC=CC=C4)C

PubChem CID

9844830

Peso molecular

416.58

Alvos associados (humanos)

SOAT1 Tchem Sterol O-acyltransferase 1 (7 Activities)

Discover Target: SOAT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)