SBI-425 - 10mM in DMSO , CAS No.1451272-71-1

CAS: 1451272-71-1 Cat. No.: S656179 Fórmula: C₁₃H₁₂ClN₃O₄S Peso molecular: 341.77 PubChem CID: 89768286

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

SBI-425 is an orally active and potent TNAP ( tissue-nonspecific alkaline phosphatase ) inhibitor ( IC 50 =16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival

In Vitro

SBI-425 treatment suppresses Foxp3 expression in CD4 + and CD8 + T cells in splenocytes from CLP-injured mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

1.19 Mouse PK parameters for SBI-425 Compds SBI-425 Cl p (mL/min/kg) 5.14 Vd (L/kg) 1.03 C max (μg/mL) 178 AUC (μg*hr/mL) 848 t 1/2 (hr) 2.3 %F 58 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 16 nM (TNAP)

Specifications

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

SBI-425 is an orally active and potent TNAP ( tissue-nonspecific alkaline phosphatase ) inhibitor ( IC 50 =16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Nomes e identificadores

• SMILES isoméricas: COC1=C(C=C(C=C1)Cl)S(=O)(=O)NC2=CN=CC(=C2)C(=O)N
• PubChem CID: 89768286
• Termos de entrada MeSH: 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide;SBI-425
• Peso molecular: 341.77

Alvos associados (humanos)

ALPL Tchem Alkaline phosphatase, tissue-nonspecific isozyme (2 Activities)

Discover Target: ALPL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Perguntas frequentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1451272-71-1, the molecular formula is C13H12ClN3O4S, and the molecular weight is 341.77 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.