Scoulerin - ≥98% , CAS No.6451-73-6

CAS: 6451-73-6 Cat. No.: S343831 Fórmula: C₁₉H₂₁NO₄ Peso molecular: 327.37 PubChem CID: 439654

GRADE & PURITY ≥98%

Synonyms

(S)-3,10-dimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline-2,9-diol | Scoulerin | HY-N1255 | (-)-Scoulerin | FT-0607361 | AKOS040760698 | SMR001233249 | (13aS)-5,8,13,13a-tetrahydro-3,10-dimethoxy-6H-dibenzo[a,g]quinolizine-2,9-diol | BSP

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Scoulerine ((-)-Scoulerine) is a potent anti-mitotic compound. Scoulerine is also an inhibitor of BACE1 (amyloid precursor protein lyase 1). Scoulerine inhibits cell proliferation, stops the cell cycle, and induces apoptosis in cancer cells.

Specifications

Sinónimos

(S)-3,10-dimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline-2,9-diol | Scoulerin | HY-N1255 | (-)-Scoulerin | FT-0607361 | AKOS040760698 | SMR001233249 | (13aS)-5,8,13,13a-tetrahydro-3,10-dimethoxy-6H-dibenzo[a,g]quinolizine-2,9-diol | BSP

Especificações e pureza

≥98%

Condições de armazenamento de armazenamento

Protected from light,Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Pureza

≥98%

Nomes e identificadores

• Pubchem Sid: 528776079
• Sorrisos canónicos: COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)O)C=C1)O
• IUPAC Name: (13aS)-3,10-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,9-diol
• InChIKey: KNWVMRVOBAFFMH-HNNXBMFYSA-N
• INCHI: 1S/C19H21NO4/c1-23-17-4-3-11-7-15-13-9-16(21)18(24-2)8-12(13)5-6-20(15)10-14(11)19(17)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3/t15-/m0/s1
• SMILES isoméricas: COC1=C(C2=C(C[C@H]3C4=CC(=C(C=C4CCN3C2)OC)O)C=C1)O
• PubChem CID: 439654
• Peso molecular: 327.37

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Alkaloids and derivatives
    • Classe Protoberberine alkaloids and derivatives

• Kingdom: Organic compounds
• Superclass: Alkaloids and derivatives
• Classe: Protoberberine alkaloids and derivatives
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Protoberberine alkaloids and derivatives
• Alternative Parents: Tetrahydroisoquinolines Anisoles Aralkylamines Alkyl aryl ethers 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Trialkylamines Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Protoberberine skeleton - Tetrahydroprotoberberine skeleton - Tetrahydroisoquinoline - Anisole - Alkyl aryl ether - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Aralkylamine - Benzenoid - Tertiary aliphatic amine - Tertiary amine - Ether - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Amine - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as protoberberine alkaloids and derivatives. These are alkaloids with a structure based on a protoberberine moiety, which consists of a 5,6-dihydrodibenzene moiety fused to a quinolizinium and forming 5,6-Dihydrodibenzo(a,g)quinolizinium skeleton.
• External Descriptors: Isoquinoline alkaloids

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

DRD1 Tclin D(1A) dopamine receptor (1 Activities)

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HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

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DRD2 Tclin Dopamine D2 receptor (23596 Activities)

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DRD1 Tclin Dopamine D1 receptor (9720 Activities)

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HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)

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AURKB Tchem Serine/threonine-protein kinase Aurora-B (6805 Activities)

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GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

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AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)

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SW480 (6023 Activities)

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A549 (127892 Activities)

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NCI-H460 (60772 Activities)

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HeLa (62764 Activities)

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MDA-MB-231 (73002 Activities)

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NCI-H23 (49055 Activities)

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FEN1 Tchem Flap endonuclease 1 (12055 Activities)

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POLI Tchem DNA polymerase iota (116820 Activities)

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POLH Tchem DNA polymerase eta (21678 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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HGC-27 (1452 Activities)

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L3MBTL1 Tchem Lethal(3)malignant brain tumor-like protein 1 (14536 Activities)

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GMNN Tbio Geminin (128009 Activities)

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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

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APOBEC3G Tchem DNA dC->dU-editing enzyme APOBEC-3G (12481 Activities)

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ATXN2 Tbio Ataxin-2 (54410 Activities)

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USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

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APAF1 Tchem Apoptotic protease-activating factor 1 (1188 Activities)

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IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

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APOBEC3F Tbio DNA dC->dU-editing enzyme APOBEC-3F (14861 Activities)

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TDP2 Tchem Tyrosyl-DNA phosphodiesterase 2 (864 Activities)

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MGC-803 (6426 Activities)

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GES1 (603 Activities)

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Alvos associados (não humanos)

Plasmodium falciparum (966862 Activities)

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

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Mecanismos de ação

Propriedades químicas e físicas

• Sensibilidade: Moisture sensitive；Light sensitive
• Índice de refração: n20D1.68 (Predicted)
• Ponto de ebulição (°C): ~503.3° C at 760 mmHg (Predicted)
• Ponto de fusão (°C): >165° C (dec.)
• Peso molecular: 327.400 g/mol
• XLogP3: 2.600
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 327.147 Da
• Monoisotopic Mass: 327.147 Da
• Topological Polar Surface Area: 62.200 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 447.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referências

1. Xiaoli Guo, Tingting Zhu, Xixi Yu, Xin Yi, Longhao Li, Xiaoying Qu, Zhe Zhang, Yuanping Hao, Wanchun Wang.  (2022)  Betamethasone-loaded dissolvable microneedle patch for oral ulcer treatment.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:36577344] [10.1016/j.colsurfb.2022.113100]

2. Lihua Zhou, Yayun Wu, Yuan Luo, Hongfeng Li, Xiaoqing Meng, Chuangjun Liu, Jingjing Xiang, Pengfei Zhang, Ping Gong, Lintao Cai.  (2019)  Mitochondria-Localized Self-Reporting Small-Molecule-Decorated Theranostic Agents for Cancer-Organelle Transporting and Imaging.  ACS Applied Bio Materials,      [PMID:35021459] [10.1021/acsabm.9b00811]

3. Fengling Wu, Qiuju Miao, Junying Zhou, Ruixia Guo, Mengyu Chen, Ningyao Tong, Yamin Zhao, Luojie Qiu, Liping Han, Siyu Li, Cheng Chen, Shenyu Yang, Lei Chang.  (2025)  Therapeutic strategies: Bioactive hydrogels oxidized sodium alginate/strontium/betamethasone for preventing intrauterine adhesion.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39855500] [10.1016/j.ijbiomac.2025.140220]