SP187 - Moligand™,10mM in DMSO , CAS No.615253-61-7

CAS: 615253-61-7 Cat. No.: S656085 Fórmula: C₁₆H₃₃NO₅ Peso molecular: 319.44 PubChem CID: 503982

GRAU & PUREZA Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

SP187 is a host-targeted iminosugar with activity against filovirus infections in vitro and in vivo. SP187 is active against influenza and dengue in vivo.

In Vitro

The antiviral activity of iminosugar SP187 (UV-4) in vitro against EBOV and MARV is assessed using a yield-plaque assay format and the IC 50 is determined. Antiviral activity for SP187 is observed with IC 50 of 29.97 and 47.72 μM for EBOV and MARV, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The efficacy of SP187 (UV-4), the active free base component of UV-4B, and UV-5, the most potent iminosugar tested in vitro, is first assessed using a mouse model of EBOV infection. In this study, C57Bl/6 mice are administered 10 or 100 mg/kg of SP187 or UV-5 via oral gavage or IP injection. Dosing started ~1h before infection with ~1000 pfu of mouse-adapted EBOV and is repeated BID for 10 days at approximately 12 hour intervals for UV-5 or TID at approximately 8 hour intervals for SP187. The selected doses and schedule are based on tolerability studies in naïve mice. No efficacy is observed in the iminosugar treated mice as compared to the vehicle control . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 29.97 μM (EBOV), 47.72 μM (MARV)

Especificações

Especificações e pureza

Moligand™,10mM in DMSO

Mecanismos bioquímicos e fisiológicos

SP187 is a host-targeted iminosugar with activity against filovirus infections in vitro and in vivo. SP187 is active against influenza and dengue in vivo.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

INHIBITOR

Nomes e identificadores

SMILES isoméricas

COCCCCCCCCCN1C[C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O

CAS alternativo

615253-61-7

PubChem CID

503982

Termos de entrada MeSH

3,4,5-piperidinetriol, 2-(hydroxymethyl)-1-(9-methoxynonyl)-, (2R,3R,4R,5S)-;N-(9-methoxynonyl)-1-deoxynojirimycin;N-(9-methoxynonyl)-1-deoxynojirimycin hydrochloride;N-9-methoxynonyldeoxynojirimycin;N-9-methoxynonyldeoxynojirimycin hydrochloride;SP-187;S

Peso molecular

319.44

Perguntas frequentes

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 615253-61-7, the molecular formula is C16H33NO5, and the molecular weight is 319.44 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.