SPR206 acetate - ≥99% , CAS No.2408422-41-1

CAS: 2408422-41-1 Cat. No.: S650343 Fórmula: C₅₂H₈₂ClN₁₅O₁₂.xC₂H₄O₂

GRADE & PURITY ≥99%

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Visão geral

SPR206 acetate is a polymyxin analog with antibiotic activity against Gram-negative pathogens , including multidrug-resistant (MDR) variants. SPR206 acetate has an anti-bacterial infection effect by interacting with the bacterium’s outer membrane. The MIC values of SPR206 acetate against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301 are both 0.125 mg/L

In Vitro

SPR206 exhibits strong anti-microbial properties against Gram-negative bacteria. The MIC values of SPR206 against E. coli IHMA558090, E. coli ATCC 25922, K. pneumonia ATCC 13882, P. aeruginosa ATCC 27853, A. baumannii NCTC13424 and A. baumannii ATCC 19003 are 8 mg/L, 0.125 mg/L, 0.125 mg/L, 0.25 mg/L, 0.06 mg/L and 0.125 mg/L, respectively, together with lower cytotoxicity. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SPR206 (0.125-30 mg/kg; intravenous injection or subcutaneous injection; every 8 hours or every 4 hours; for 16 hours or 24 hours; neutropenic mice) treatment reduces the burden of Pa14 and NCTC13301 in lung tissue and in the thigh model. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Neutropenic mice infected Pa14 or NCTC13301Dosage: 3 mg/kg, 10 mg/kg, 20 mg/kg, 30 mg/kg (intravenous injection); 0.125 mg/kg, 0.5 mg/kg, 1 mg/kg, 4 mg/kg (subcutaneous injection) Administration: Intravenous injection or subcutaneous injection; every 8 hours or every 4 hours; for 16 hours or 24 hours Result: In lung tissue, reduced the burden of Pa14 and NCTC13301 by 1.5 and 3.6 log 10 CFU/mL. In the thigh model, reduced the burden of Ab13301 by 3.4 and 4.3 log 10 CFU/g.

Form:Solid

IC50& Target:MIC: 0.125 mg/L ( Pseudomonas aeruginosa Pa14) and 0.125 mg/L ( Acinetobacter baumannii NCTC13301)

Specifications

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

SPR206 acetate is a polymyxin analog with antibiotic activity against Gram-negative pathogens , including multidrug-resistant (MDR) variants. SPR206 acetate has an anti-bacterial infection effect by interacting with the bacterium’s outer membrane. The MIC

Condições de armazenamento de armazenamento

Store at -20°C,Desiccated

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥99%

Nomes e identificadores

• Sorrisos canónicos: O=C(N[C@@H](CC(C)C)C(N[C@@H](CCN)C(N[C@@H](CCN)C(N1)=O)=O)=O)[C@H](NC([C@H](CCN)NC([C@H](CCNC([C@@H]1[C@H](O)C)=O)NC([C@H](CN)NC([C@@H](NC(C[C@@H](C2=CC=CC(Cl)=C2)CN)=O)[C@H](O)C)=O)=O)=O)=O)CC3=CC=CC=C3.CC(O)=O.[x]

Propriedades químicas e físicas

• Solubilidade: DMSO : ≥ 100 mg/mL

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2408422-41-1, the molecular formula is C52H82ClN15O12.xC2H4O2.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.