SR18662 - ≥99% , CAS No.S414256

CAS: S414256 Cat. No.: S414256 Fórmula: C₁₆H₁₉Cl₂N₃O₄S Peso molecular: 420.31

GRADE & PURITY ≥99%

Synonyms

(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Information

SR18662 SR18662 is an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM. SR18662 reduces the viability of multiple colorectal cancer cell lines. SR18662 induces apoptosis .

Targets

KLF5 (Cell-free assay) 4.4 nM

In vitro

Treatment with SR18662 significantly reduces growth and proliferation of CRC cells. SR18662 shows improved efficacy in reducing viability of multiple CRC cell lines. Flow cytometry analysis following SR18662 treatment shows an increase in cells captured in either S or G2/M phases of the cell cycle and a significant increase in the number of apoptotic cells. SR18662 treatment also reduces the expression of cyclins and components of MAPK and WNT signaling pathways.

In vivo

A significant dose-dependent inhibition of xenograft growth in mice is observed following SR18662 treatment that exceeds the effect of ML264 at equivalent doses. SR18662 is potential for colorectal cancer therapy.

Cell Research(from reference)

Cell lines：DLD-1, HCT116, HT29 and SW620 colorectal cancer cell lines 

Concentrations：0.001 μM-20 μM 

Incubation Time：24 h 

Specifications

Sinónimos

(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

SR18662 is an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM. SR18662 reduces the viability of multiple colorectal cancer cell lines. SR18662 induces apoptosis.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥99%

Nomes e identificadores

• Sorrisos canónicos: C[S](=O)(=O)N1CCN(CC1)C(=O)CNC(=O)/C=C/C2=CC(=C(Cl)C=C2)Cl
• Peso molecular: 420.31

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 84 mg/mL (199.85 mM); Water: Insoluble; Ethanol: Insoluble