SRX3207 - ≥98% , CAS No.2254693-15-5

CAS: 2254693-15-5 Cat. No.: S414288 Fórmula: C₂₉H₂₉N₇O₃S  Peso molecular: 555.65 PubChem CID: 137357450

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Information

SRX3207 is an orally active dual inhibitor ofSyk-PI3Kwith IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM forSyk,Zap70,BRD41,BRD42,PI3K alpha,PI3K delta,PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity.

Targets

Syk (cell-free assay); PI3K alpha (cell-free assay); PI3K delta (cell-free assay); BRD41 (cell-free assay); BRD42 (cell-free assay) 32131,39.9 nM; 244 nM; 388 nM; 3070 nM; 3070 nM

In vivo

SRX3207 blocks both PI3K and Syk in MΦs thereby activating innate and adaptive antitumor immunity in vivo.

Specifications

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and inc

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥98%

Propriedades do produto

• ALogP: 4.59
• Contagem HBD: 1
• Ligação rotativa: 7

Nomes e identificadores

• Pubchem Sid: 488203021
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488203021
• Sorrisos canónicos: CC1=NN(C=C1CN2CCC2)C3=NC(=NC=C3)NC4=CC=C(C=C4)C5=CSC6=C5OC(=CC6=O)N7CCOCC7
• IUPAC Name: 3-[4-[[4-[4-(azetidin-1-ylmethyl)-3-methylpyrazol-1-yl]pyrimidin-2-yl]amino]phenyl]-5-morpholin-4-ylthieno[3,2-b]pyran-7-one
• InChIKey: ZZVOPDBZUNUMPR-UHFFFAOYSA-N
• INCHI: 1S/C29H29N7O3S/c1-19-21(16-34-9-2-10-34)17-36(33-19)25-7-8-30-29(32-25)31-22-5-3-20(4-6-22)23-18-40-28-24(37)15-26(39-27(23)28)35-11-13-38-14-12-35/h3-8,15,17-18H,2,9-14,16H2,1H3,(H,30,31,32)
• PubChem CID: 137357450
• Peso molecular: 555.65

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 33 mg/mL (59.38 mM); Water: Insoluble; Ethanol: Insoluble
• DMSO (mg/mL) Solubilidade máxima: 33
• DMSO (mM) Solubilidade máxima: 59.3899037163682
• Água (mg/mL) Solubilidade máxima: ＜1
• Peso molecular: 555.700 g/mol
• XLogP3: 4.000
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 7
• Exact Mass: 555.205 Da
• Monoisotopic Mass: 555.205 Da
• Topological Polar Surface Area: 126.000 Ų
• Heavy Atom Count: 40
• Formal Charge: 0
• Complexity: 923.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2254693-15-5, the molecular formula is C29H29N7O3S?, and the molecular weight is 555.65 g/mol. InChIKey ZZVOPDBZUNUMPR-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.