Stauprimide - ≥99% , CAS No.154589-96-5

CAS: 154589-96-5 Cat. No.: S139814 Fórmula: C₃₅H₂₈N₄O₅ Peso molecular: 584.62 PubChem CID: 46245328

GRADE & PURITY ≥99%

Synonyms

Q7604751 | [9S-(9alpha,10beta,11beta,13alpha)]-N-(2,3,10,11,12,1 3-Hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epo xy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j] [1,7]benzodiazonin-11-yl)-N-methylbenzamide | HY-N6747 | N-((9S,10R,11R,13R)-2,3,10,1

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Stauprimide is an indolocarbazole semi-synthetic small molecule shown to significantly increase the efficiency of directed embryonic stem cell differentiation. Stauprimide inhibits the nuclear localization of NME2, blocking and downregulating c-Myc expression. The expression of c-Myc is crucial for embryonic stem cell self-renewal, and intervention by Stauprimide allows for more efficient lineage-specific differentiation. NME2 is also indicated to be upregulated in certain cancers, indicating further application for the blocking action of Stauprimide
An indolocarbazole promoter of embryonic stem cell differentiation.

Specifications

Sinónimos

Q7604751 | [9S-(9alpha,10beta,11beta,13alpha)]-N-(2,3,10,11,12,1 3-Hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epo xy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j] [1,7]benzodiazonin-11-yl)-N-methylbenzamide | HY-N6747 | N-((9S,10R,11R,13R)-2,3,10,1

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

Small molecule that primes embryonic stem cells (ESCs) for differentiation. Interacts with NME2 and inhibits its nuclear translocation. Increases the efficiency of directed differentiation of mouse and human ESCsin vitro.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥99%

Nomes e identificadores

Pubchem Sid

528767304

Sorrisos canónicos

CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC

IUPAC Name

N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16,18-dioxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide

InChIKey

MQCCJEYZKWZQHU-MPRCCEKMSA-N

INCHI

1S/C35H28N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31H,17H2,1-3H3,(H,36,40,41)/t23-,24-,31-,35+/m1/s1

SMILES isoméricas

C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC

WGK Alemanha

3

PubChem CID

46245328

Peso molecular

584.62

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Indoles and derivatives
      • Subclass Carbazoles
        • Level5 Pyrrolocarbazoles
          • Level6 Indolocarbazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Indoles and derivatives
• Subclass: Carbazoles
• Intermediate Tree Nodes: Pyrrolocarbazoles
• Direct Parent: Indolocarbazoles
• Alternative Parents: Pyrrolo[2,3-a]carbazoles Pyrroloindoles Phthalimides Benzamides Indoles Benzoyl derivatives Oxanes Tertiary carboxylic acid amides Pyrroles N-unsubstituted carboxylic acid imides Heteroaromatic compounds Tertiary amines Amino acids and derivatives Oxacyclic compounds Azacyclic compounds Dialkyl ethers Hydrocarbon derivatives Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Indolocarbazole - Pyrrolo[2,3-a]carbazole - Pyrroloindole - Phthalimide - Isoindolone - Benzamide - Benzoic acid or derivatives - Indole - Isoindoline - Isoindole or derivatives - Benzoyl - Monocyclic benzene moiety - Benzenoid - Oxane - Carboxylic acid imide - Heteroaromatic compound - Tertiary carboxylic acid amide - Carboxylic acid imide, n-unsubstituted - Pyrrole - Amino acid or derivatives - Carboxamide group - Tertiary amine - Azacycle - Oxacycle - Ether - Dialkyl ether - Carboxylic acid derivative - Amine - Hydrocarbon derivative - Organic oxide - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as indolocarbazoles. These are polycyclic aromatic compounds containing an indole fused to a carbazole.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propriedades químicas e físicas

• Solubilidade: Soluble in DMSO}
• Sensibilidade: Light sensitive
• Ponto de fusão (°C): 145°C
• Peso molecular: 584.600 g/mol
• XLogP3: 4.800
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 584.206 Da
• Monoisotopic Mass: 584.206 Da
• Topological Polar Surface Area: 94.800 Ų
• Heavy Atom Count: 44
• Formal Charge: 0
• Complexity: 1220.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1