(±)-Sulfinpyrazone - Moligand™, 10mM in DMSO , Antagonist of FPR1;Inhibitor of Urate anion exchanger 1, CAS No.57-96-5, Antagonist of FPR1;Inhibitor of Urate anion exchanger 1

CAS: 57-96-5 Cat. No.: S424870 Fórmula: C₂₃H₂₀N₂O₃S Peso molecular: 404.48 Número CE: 200-357-4 PubChem CID: 5342

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

sulfinpyrazone|57-96-5|Sulphinpyrazone|Anturane|(+/-)-SULFINPYRAZONE|Sulfinpyrazon|Anturan|Diphenylpyrazone|Sulfoxyphenylpyrazolidine|Anturanil|Anturidin|Enturen|Anturano|1,2-Diphenyl-4-(2-(phenylsulfinyl)ethyl)pyrazolidine-3,5-dione|USAF GE-13|Sulfinpyra

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Product Describtion:

Sulfinpyrazone is a free radical scavenger that is an inhibitor of organic anion transporters (OATP) and is an effective uricosuric chemical. It is a proposed nonselective UGT (UDP-glucuronosyltransferases) inhibitor. The transport of sulfinpyrazone in MDCKII-MRP1 cells is associated with GSH export, except in high concentrations, and is a substrate for MRP2 (multidrug resistance protein).

Product Application：

cleaning products，cosmetics，food and beverages，forensics and toxicology，personal care，pharmaceutical (small molecule)，veterinary

Specifications

Sinónimos

sulfinpyrazone | 57-96-5 | Sulphinpyrazone | Anturane | (+/-)-SULFINPYRAZONE | Sulfinpyrazon | Anturan | Diphenylpyrazone | Sulfoxyphenylpyrazolidine | Anturanil | Anturidin | Enturen | Anturano | 1,2-Diphenyl-4-(2-(phenylsulfinyl)ethyl)pyrazolidine-3,5-dione | USAF GE-13 | Sulfinpyra

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Sulfamethoxazole, one of the most studied inhibitors of Platelet Cox, is an acid excretory agent that reabsorbs Competitive inhibition acid in the proximal tubules of the kidney.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

ANTAGONIST, INHIBITOR

Mecanismo de ação

Antagonist of FPR1;Inhibitor of Urate anion exchanger 1

Nomes e identificadores

• Pubchem Sid: 528753462
• Sorrisos canónicos: C1=CC=C(C=C1)N2C(=O)C(C(=O)N2C3=CC=CC=C3)CCS(=O)C4=CC=CC=C4
• IUPAC Name: 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenylpyrazolidine-3,5-dione
• InChIKey: MBGGBVCUIVRRBF-UHFFFAOYSA-N
• INCHI: 1S/C23H20N2O3S/c26-22-21(16-17-29(28)20-14-8-3-9-15-20)23(27)25(19-12-6-2-7-13-19)24(22)18-10-4-1-5-11-18/h1-15,21H,16-17H2
• SMILES isoméricas: C1=CC=C(C=C1)N2C(=O)C(C(=O)N2C3=CC=CC=C3)CCS(=O)C4=CC=CC=C4
• WGK Alemanha: 3
• RTECS: UQ8575000
• PubChem CID: 5342
• Peso molecular: 404.48

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Phenyl sulfoxides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Phenyl sulfoxides
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenyl sulfoxides
• Alternative Parents: Pyrazolidinones 1,3-dicarbonyl compounds Sulfoxides Carboxylic acid hydrazides Sulfinyl compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Phenyl sulfoxide - Pyrazolidinone - 1,3-dicarbonyl compound - Pyrazolidine - Carboxylic acid hydrazide - Sulfoxide - Carboxylic acid derivative - Azacycle - Organoheterocyclic compound - Sulfinyl compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteromonocyclic compound
• Descrição: This compound belongs to the class of organic compounds known as phenyl sulfoxides. These are organosulfur compounds containing a sulfoxide group substituted with a phenyl group.
• External Descriptors: sulfoxide - pyrazolidines

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

SLC22A12 Tclin Solute carrier family 22 member 12 (1 Activities)

Discover Target: SLC22A12

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FPR1 Tchem fMet-Leu-Phe receptor (1 Activities)

Discover Target: FPR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NAPRT Tchem Nicotinate phosphoribosyltransferase (0 Activities)

Discover Target: NAPRT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Ponto de fusão (°C): 131 °C
• Peso molecular: 404.500 g/mol
• XLogP3: 2.300
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 404.119 Da
• Monoisotopic Mass: 404.119 Da
• Topological Polar Surface Area: 76.900 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 571.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1