SY-LB-57 - ≥99% , CAS No.2253719-35-4

CAS: 2253719-35-4 Cat. No.: S646783 Fórmula: C₁₆H₁₃N₃O Peso molecular: 263.29

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

SY-LB-57 is a highly potent bone morphogenetic protein ( BMP ) receptor signaling agonist. SY-LB-57 can be used in studies of diseases such as fractures and pulmonary arterial hypertension.

In Vitro

SY-LB-57 (0.01-1000 μM, 24 h) can significantly induce cell proliferation at concentrations below 10 µM with an IC 50 value of 807.93 µM in C2C12 cells. SY-LB-57 (0.01-10 μM, 15-30 min) increases the phosphorylation of Smad protein and promotes p-Smad nuclear translocation while activates the PI3K/Akt pathway and induces cytoplasmic localization of p-Akt. SY-LB-57 (0.01-10 μM, 24 h) can induce cell cycle shift towards proliferation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: C2C12 cells Concentration: 0.01-1000 μM Incubation Time: 24 hours Result: Resulted in 85% reduction in the cell viability of C2C12 at 1 mM while increased cell viability by 280%, 290%, 200%, 150% and 50% at 0.01 µM, 0.1 µM, 1 µM, 10 µM and 100 µM, respectively. Western Blot AnalysisCell Line: C2C12 cells Concentration: 0.01-10 μM Incubation Time: 15min or 30 min Result: Significantly increased phosphorylation of Smad protein, 50% to 257% higher compared to control after 30 min. Showed a significant increase in p-Akt expression levels, exceeding the control by 667-1081% after 15 min. Cell Cycle AnalysisCell Line: C2C12 cells Concentration: 0.01-10 μM Incubation Time: 24 hours Result: Resulted in a significant decrease in the percentage of G0/G1 phase cells and a dramatic increase in S and G2/M phase cells.

Form:Solid

Specifications

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

SY-LB-57 is a highly potent bone morphogenetic protein ( BMP ) receptor signaling agonist. SY-LB-57 can be used in studies of diseases such as fractures and pulmonary arterial hypertension.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥99%

Nomes e identificadores

Sorrisos canónicos

COC1=CC2=C(NC(C3=NC4=CC=CC=C4N3)=C2)C=C1

Peso molecular

263.29

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2253719-35-4, the molecular formula is C16H13N3O, and the molecular weight is 263.29 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.